Sandbox jo: Difference between revisions

Latest revision as of 21:30, 6 August 2014


Diagnostic Markers	Significance
Anti-HDV IgG antibody	Positive in persons exposed to HDV Persists, even after viral clearance
Anti-HDV IgM antibody	Positive in acute infection Negative in past infection Persists in many patients with chronic infection
HDV RNA	Qualitative Marker of HDV replication Positive in chronic infection Negative in spontaneous or treatment-induced viral clearance Quantitative Useful in monitoring or predicting treatment response
HBsAg	Qualitative Must be positive for HDV infectivity Quantitative Positively correlated with HDV RNA Falling titer signals HBsAg loss, and hence HDV clearance Useful in monitoring or predicting treatment response
HBeAg	Negative in an estimated 85% of patients Associated with detectable anti-HBe
HBV DNA	Quantitative Suppressed by HDV Negative or low levels in most patients May be increased in patients with detectable HBeAg Can reactivate after spontaneous or treatment-induced clearance of HDV
ALT	Increased in most patients Does not correlate well with degree of histological liver damage

@@ Line 29: / Line 29: @@
 :*Must be positive for HDV infectivity
 '''Quantitative'''
-:*
+:*Positively correlated with HDV RNA
+:*Falling titer signals HBsAg loss, and hence HDV clearance
+:*Useful in monitoring or predicting treatment response
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" | '''HBV DNA'''
+| style="padding: 5px 5px; background: #DCDCDC;" | '''HBeAg'''
 | style="padding: 5px 5px; background: #F5F5F5;" |
+*Negative in an estimated 85% of patients
+*Associated with detectable anti-HBe
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" | '''HBV DNA Polymerase'''
+| style="padding: 5px 5px; background: #DCDCDC;" | '''HBV DNA'''
 | style="padding: 5px 5px; background: #F5F5F5;" |
+'''Quantitative'''
+:*Suppressed by HDV
+:*Negative or low levels in most patients
+:*May be increased in patients with detectable HBeAg
+:*Can reactivate after spontaneous or treatment-induced clearance of HDV
 |-
-| style="padding: 5px 5px; background: #DCDCDC;" | '''HBV DNA Polymerase'''
+| style="padding: 5px 5px; background: #DCDCDC;" | '''ALT'''
 | style="padding: 5px 5px; background: #F5F5F5;" |
+*Increased in most patients
+*Does not correlate well with degree of histological liver damage
 |-
 |}