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| {{Infobox Disease
| | #Redirect[[Hemolytic anemia differential diagnosis]] |
| | Name = {{PAGENAME}}
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| | Image =
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| | Caption =
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| | DiseasesDB =
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| | ICD10 = {{ICD10|D|59|0|d|55}}
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| | ICD9 = {{ICD9|283}}
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| | OMIM =
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| | MedlinePlus =
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| | eMedicineSubj =
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| | eMedicineTopic =
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| | MeshID =
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| }}
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| {{SI}}
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| {{CMG}}
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| {{EH}}
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| ==Overview==
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| '''Drug-induced autoimmune hemolytic anaemia''' is a form of [[hemolytic anaemia]].
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| ==Differential diagnosis of underlying causes==
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| [[Penicillin]] in high doses can induce immune mediated [[hemolysis]]<ref name="pmid10815791">{{cite journal |author=Stroncek D, Procter JL, Johnson J |title=Drug-induced hemolysis: cefotetan-dependent hemolytic anemia mimicking an acute intravascular immune transfusion reaction |journal=Am. J. Hematol. |volume=64 |issue=1 |pages=67–70 |year=2000 |month=May |pmid=10815791 |doi= |url=http://dx.doi.org/10.1002/(SICI)1096-8652(200005)64:1<67::AID-AJH12>3.0.CO;2-Z}}</ref> via the [[hapten]] mechanism in which antibodies are targeted against the combination of [[penicillin]] in association with [[red blood cell]]s. Complement is activated by the attached antibody leading to the removal of [[red blood cell]]s by the spleen.
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| The drug itself can be targeted by the [[immune system]], e.g. by [[IgE]] in a [[Type I hypersensitivity reaction]] to [[penicillin]], rarely leading to [[anaphylaxis]].
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| ==References==
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| {{reflist|2}}
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| {{Hematology}}
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| {{SIB}}
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| [[Category:Blood disorders]]
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| [[Category:Hematology]]
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| {{WH}}
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| {{WS}}
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