Cerebral venous sinus thrombosis natural history: Difference between revisions

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{{Cerebral venous sinus thrombosis}}
{{Cerebral venous sinus thrombosis}}


In 2004 the first adequately large scale study on the natural history and long-term prognosis of this condition was reported and showed that at 16 months followup: 57.1% of patients had full recovery, 29.5%/2.9%/2.2% had respectively minor/moderate/severe symptoms or impairments, and 8.3% had died. Severe impairment or death were more likely in those aged over 37 years, male, affected by coma, mental status disorder, intracerebral hemorrhage, thrombosis of the deep cerebral venous system, central nervous system infection and cancer.<ref name="pmid14976332">{{cite journal |author=Ferro JM, Canhão P, Stam J, Bousser MG, Barinagarrementeria F |title=Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT) |journal=Stroke |volume=35 |issue=3 |pages=664–70 |year=2004 |pmid=14976332 |doi=10.1161/01.STR.0000117571.76197.26 |url=http://stroke.ahajournals.org/cgi/content/full/35/3/664}}</ref> A subsequent [[systematic review]] of nineteen studies in 2006 showed that mortality is about 5.6% during hospitalisation and 9.4% in total, while of the survivors 88% make a total or near-total recovery. After several months, two thirds of the cases has resolution ("recanalisation") of the clot. The rate of recurrence was low (2.8%).<ref>{{cite journal |author=Dentali F, Gianni M, Crowther MA, Ageno W |title=Natural history of cerebral vein thrombosis: a systematic review |journal=Blood |volume=108 |issue=4 |pages=1129–34 |year=2006 |pmid=16609071 |doi=10.1182/blood-2005-12-4795}}</ref>
{{CMG}} {{AE}} {{ SharmiB}}
 
==Overview==
 
Common complications of [[cerebral venous thrombosis]] include [[neurological]] deficits, [[coma]], and death.
 
==Natural History, Complications, and Prognosis==
 
===Natural History===
*The symptoms of [[cerebral venous thrombosis]](CVT) usually develop in the first decade of life, and start with [[symptoms]] such as [[headache]], [[seizures]], [[neurological]] deficits, [[visual]] [[impairment]], decreased level of [[consciousness]]. <ref name="BushnellSaposnik2014">{{cite journal|last1=Bushnell|first1=Cheryl|last2=Saposnik|first2=Gustavo|title=Evaluation and Management of Cerebral Venous Thrombosis|journal=CONTINUUM: Lifelong Learning in Neurology|volume=20|year=2014|pages=335–351|issn=1080-2371|doi=10.1212/01.CON.0000446105.67173.a8}}</ref><ref name="FaizVetvik2018">{{cite journal|last1=Faiz|first1=Kashif Waqar|last2=Vetvik|first2=Kjersti Grøtta|last3=Harper|first3=Charlotte Elena|last4=Kristoffersen|first4=Espen Saxhaug|title=Cerebral venetrombose – forekomst, diagnostikk og behandling|journal=Tidsskrift for Den norske legeforening|year=2018|issn=0029-2001|doi=10.4045/tidsskr.17.1047}}</ref>
 
* 15% of patients with CVT may progress to develop residual [[epilepsy]], [[cognitive]] impairment, recurrent CVT or systemic [[thromboembolism]].
 
===Complications===
*Common [[complications]] of [[cerebral venous thrombosis]] (CVT) include:
** [[Hydrocephalus]]<ref name="FaizVetvik2018">{{cite journal|last1=Faiz|first1=Kashif Waqar|last2=Vetvik|first2=Kjersti Grøtta|last3=Harper|first3=Charlotte Elena|last4=Kristoffersen|first4=Espen Saxhaug|title=Cerebral venetrombose – forekomst, diagnostikk og behandling|journal=Tidsskrift for Den norske legeforening|year=2018|issn=0029-2001|doi=10.4045/tidsskr.17.1047}}</ref><ref name="BushnellSaposnik2014">{{cite journal|last1=Bushnell|first1=Cheryl|last2=Saposnik|first2=Gustavo|title=Evaluation and Management of Cerebral Venous Thrombosis|journal=CONTINUUM: Lifelong Learning in Neurology|volume=20|year=2014|pages=335–351|issn=1080-2371|doi=10.1212/01.CON.0000446105.67173.a8}}</ref>
** [[Cognitive impairment]]
** [[Neurological]] deficit
** Residual [[epilepsy]]
** [[Coma]]
** Death
 
===Prognosis===
 
The [[prognosis]] of CVT is favorable than other [[strokes]]. Complete functional [[recovery]] has been reported in 75% of [[patients]] but 15% of [[patients]] die or become dependent.<ref name="FerroCanhão2004">{{cite journal|last1=Ferro|first1=José M.|last2=Canhão|first2=Patrícia|last3=Stam|first3=Jan|last4=Bousser|first4=Marie-Germaine|last5=Barinagarrementeria|first5=Fernando|title=Prognosis of Cerebral Vein and Dural Sinus Thrombosis|journal=Stroke|volume=35|issue=3|year=2004|pages=664–670|issn=0039-2499|doi=10.1161/01.STR.0000117571.76197.26}}</ref> Study showed women has better [[prognosis]] than men. 81% of women recovered completely while only 71 % of men had so.<ref name="CoutinhoFerro2009">{{cite journal|last1=Coutinho|first1=Jonathan M.|last2=Ferro|first2=José M.|last3=Canhão|first3=Patrícia|last4=Barinagarrementeria|first4=Fernando|last5=Cantú|first5=Carlos|last6=Bousser|first6=Marie-Germaine|last7=Stam|first7=Jan|title=Cerebral Venous and Sinus Thrombosis in Women|journal=Stroke|volume=40|issue=7|year=2009|pages=2356–2361|issn=0039-2499|doi=10.1161/STROKEAHA.108.543884}}</ref> Recurrent [[thrombosis]] is a common complication in CVT, around 6.5% per year but mostly in [[patients]] who are not on [[anticoagualnts]].<ref name="FerroCanhão2004">{{cite journal|last1=Ferro|first1=José M.|last2=Canhão|first2=Patrícia|last3=Stam|first3=Jan|last4=Bousser|first4=Marie-Germaine|last5=Barinagarrementeria|first5=Fernando|title=Prognosis of Cerebral Vein and Dural Sinus Thrombosis|journal=Stroke|volume=35|issue=3|year=2004|pages=664–670|issn=0039-2499|doi=10.1161/01.STR.0000117571.76197.26}}</ref>


==References==
==References==
{{Reflist|2}}


{{Reflist|2}}
[[Category:Neurology]]
[[Category:Disease]]

Latest revision as of 22:08, 25 July 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sharmi Biswas, M.B.B.S

Overview

Common complications of cerebral venous thrombosis include neurological deficits, coma, and death.

Natural History, Complications, and Prognosis

Natural History

Complications

Prognosis

The prognosis of CVT is favorable than other strokes. Complete functional recovery has been reported in 75% of patients but 15% of patients die or become dependent.[3] Study showed women has better prognosis than men. 81% of women recovered completely while only 71 % of men had so.[4] Recurrent thrombosis is a common complication in CVT, around 6.5% per year but mostly in patients who are not on anticoagualnts.[3]

References

  1. 1.0 1.1 Bushnell, Cheryl; Saposnik, Gustavo (2014). "Evaluation and Management of Cerebral Venous Thrombosis". CONTINUUM: Lifelong Learning in Neurology. 20: 335–351. doi:10.1212/01.CON.0000446105.67173.a8. ISSN 1080-2371.
  2. 2.0 2.1 Faiz, Kashif Waqar; Vetvik, Kjersti Grøtta; Harper, Charlotte Elena; Kristoffersen, Espen Saxhaug (2018). "Cerebral venetrombose – forekomst, diagnostikk og behandling". Tidsskrift for Den norske legeforening. doi:10.4045/tidsskr.17.1047. ISSN 0029-2001.
  3. 3.0 3.1 Ferro, José M.; Canhão, Patrícia; Stam, Jan; Bousser, Marie-Germaine; Barinagarrementeria, Fernando (2004). "Prognosis of Cerebral Vein and Dural Sinus Thrombosis". Stroke. 35 (3): 664–670. doi:10.1161/01.STR.0000117571.76197.26. ISSN 0039-2499.
  4. Coutinho, Jonathan M.; Ferro, José M.; Canhão, Patrícia; Barinagarrementeria, Fernando; Cantú, Carlos; Bousser, Marie-Germaine; Stam, Jan (2009). "Cerebral Venous and Sinus Thrombosis in Women". Stroke. 40 (7): 2356–2361. doi:10.1161/STROKEAHA.108.543884. ISSN 0039-2499.