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==Overview==
==Overview==
Silent thyroiditis may be caused by the activation of helper T cells, [[genetic]] factors, and autoimmune antibodies against [[Thyrotropin receptor|thyrotropin receptors]]
Silent thyroiditis may be caused by the activation of [[T helper cell|helper T cells]] and [[Cytotoxic T cell|cytotoxic T cells]], [[genetic]] factors, and [[autoimmune]] antibodies.


==Causes==
==Causes==
The cause of this type of thyroiditis is unknown.
Silent thyroiditis is usually caused by:<ref name="pmid3415401">{{cite journal |vauthors=Volpé R |title=Is silent thyroiditis an autoimmune disease? |journal=Arch. Intern. Med. |volume=148 |issue=9 |pages=1907–8 |year=1988 |pmid=3415401 |doi= |url=}}</ref><ref name="pmid22443972">{{cite journal |vauthors=Samuels MH |title=Subacute, silent, and postpartum thyroiditis |journal=Med. Clin. North Am. |volume=96 |issue=2 |pages=223–33 |year=2012 |pmid=22443972 |doi=10.1016/j.mcna.2012.01.003 |url=}}</ref><ref name="pmid6606505">{{cite journal |vauthors=Farid NR, Hawe BS, Walfish PG |title=Increased frequency of HLA-DR3 and 5 in the syndromes of painless thyroiditis with transient thyrotoxicosis: evidence for an autoimmune aetiology |journal=Clin. Endocrinol. (Oxf) |volume=19 |issue=6 |pages=699–704 |year=1983 |pmid=6606505 |doi= |url=}}</ref><ref name="pmid3488044">{{cite journal |vauthors=Tajiri J, Higashi K, Morita M, Ohishi S, Umeda T, Sato T |title=Elevation of anti-DNA antibody titer during thyrotoxic phase of silent thyroiditis |journal=Arch. Intern. Med. |volume=146 |issue=8 |pages=1623–4 |year=1986 |pmid=3488044 |doi= |url=}}</ref>
*Abnormalities in the [[Regulatory T cell|regulatory T cells]] and cytotoxic [[T-cell|T-cells]]
*[[HLA-DR3]] and [[HLA-DR5]] involvement
*[[Antithyroid microsomal antibodies|Antithyroid antibodies]]


Silent thyroiditis is most likely [[autoimmune]].
[[Hashimoto's thyroiditis]] is also known as chronic lymphocytic thyroiditis and is, therefore, in the same "family" as silent thyroiditis. It seems that silent thyroiditis may be transient "hashitoxicosis," which is a hyperthyroidism phase before the usual hypothyroidism associated with Hashimoto's thyroiditis.


Ingestion of large or minimal amounts of [[iodine]] bring a host of different conditions and usually is not associated with silent thyroiditis.
For the factors involved in the development of silent thyroiditis, please '''[[silent thyroiditis risk factors|click here]].'''


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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Latest revision as of 00:11, 30 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]

Overview

Silent thyroiditis may be caused by the activation of helper T cells and cytotoxic T cells, genetic factors, and autoimmune antibodies.

Causes

Silent thyroiditis is usually caused by:[1][2][3][4]


For the factors involved in the development of silent thyroiditis, please click here.

References

  1. Volpé R (1988). "Is silent thyroiditis an autoimmune disease?". Arch. Intern. Med. 148 (9): 1907–8. PMID 3415401.
  2. Samuels MH (2012). "Subacute, silent, and postpartum thyroiditis". Med. Clin. North Am. 96 (2): 223–33. doi:10.1016/j.mcna.2012.01.003. PMID 22443972.
  3. Farid NR, Hawe BS, Walfish PG (1983). "Increased frequency of HLA-DR3 and 5 in the syndromes of painless thyroiditis with transient thyrotoxicosis: evidence for an autoimmune aetiology". Clin. Endocrinol. (Oxf). 19 (6): 699–704. PMID 6606505.
  4. Tajiri J, Higashi K, Morita M, Ohishi S, Umeda T, Sato T (1986). "Elevation of anti-DNA antibody titer during thyrotoxic phase of silent thyroiditis". Arch. Intern. Med. 146 (8): 1623–4. PMID 3488044.

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