Analgesic nephropathy causes: Difference between revisions
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==Overview== | ==Overview== | ||
There is a strong association between [[phenacetin]] and analgesic nephropathy which has led to the disappearing of classic analgesic nephropathy after the removal of [[phenacetin]] from the markets over 30 years ago. Although non-phenacetin [[Analgesic|analgesics]] (such as [[Non-steroidal anti-inflammatory drug|NSAIDs]], [[aspirin]] and [[acetaminophen]]) have been reported in some studies as causes to analgesic nephropathy, but there is insufficient evidence that | There is a strong association between [[phenacetin]] and analgesic nephropathy which has led to the disappearing of classic analgesic nephropathy after the removal of [[phenacetin]] from the markets over 30 years ago. Although non-phenacetin [[Analgesic|analgesics]] (such as [[Non-steroidal anti-inflammatory drug|NSAIDs]], [[aspirin]] and [[acetaminophen]]) or their combinations have been reported in some studies as causes to analgesic nephropathy, but there is insufficient evidence that suggests these drugs cause analgesic nephropathy. | ||
==Causes== | ==Causes== | ||
* There is a strong association between [[phenacetin]] and analgesic nephropathy.<ref name="pmid27900067">{{cite journal| author=Yaxley J| title=Common Analgesic Agents and Their Roles in Analgesic Nephropathy: A Commentary on the Evidence. | journal=Korean J Fam Med | year= 2016 | volume= 37 | issue= 6 | pages= 310-316 | pmid=27900067 | doi=10.4082/kjfm.2016.37.6.310 | pmc=5122661 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27900067 }} </ref> | |||
=== Phenacetin === | |||
*There is a strong association between [[phenacetin]] and analgesic nephropathy.<ref name="pmid27900067">{{cite journal| author=Yaxley J| title=Common Analgesic Agents and Their Roles in Analgesic Nephropathy: A Commentary on the Evidence. | journal=Korean J Fam Med | year= 2016 | volume= 37 | issue= 6 | pages= 310-316 | pmid=27900067 | doi=10.4082/kjfm.2016.37.6.310 | pmc=5122661 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27900067 }} </ref> | |||
*The classic analgesic nephropathy is disappearing after the removal of [[phenacetin]] from the markets over 30 years ago.<ref name="pmid16891638">{{cite journal| author=Mihatsch MJ, Khanlari B, Brunner FP| title=Obituary to analgesic nephropathy--an autopsy study. | journal=Nephrol Dial Transplant | year= 2006 | volume= 21 | issue= 11 | pages= 3139-45 | pmid=16891638 | doi=10.1093/ndt/gfl390 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16891638 }} </ref> | *The classic analgesic nephropathy is disappearing after the removal of [[phenacetin]] from the markets over 30 years ago.<ref name="pmid16891638">{{cite journal| author=Mihatsch MJ, Khanlari B, Brunner FP| title=Obituary to analgesic nephropathy--an autopsy study. | journal=Nephrol Dial Transplant | year= 2006 | volume= 21 | issue= 11 | pages= 3139-45 | pmid=16891638 | doi=10.1093/ndt/gfl390 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16891638 }} </ref> | ||
* Although non-phenacetin [[Analgesic|analgesics]] (such as [[Non-steroidal anti-inflammatory drug|NSAIDs]], [[aspirin]] and [[acetaminophen]]) have been reported in some studies as causes to analgesic nephropathy, but there is insufficient evidence that | |||
* Further | === NSAIDs, aspirin and acetaminophen === | ||
* Although non-phenacetin [[Analgesic|analgesics]] (such as [[Non-steroidal anti-inflammatory drug|NSAIDs]], [[aspirin]] and [[acetaminophen]]) and their combinations have been reported in some studies as causes to analgesic nephropathy, but there is insufficient evidence that suggests these drugs cause analgesic nephropathy.<ref name="pmid11115060">{{cite journal| author=Feinstein AR, Heinemann LA, Curhan GC, Delzell E, Deschepper PJ, Fox JM | display-authors=etal| title=Relationship between nonphenacetin combined analgesics and nephropathy: a review. Ad Hoc Committee of the International Study Group on Analgesics and Nephropathy. | journal=Kidney Int | year= 2000 | volume= 58 | issue= 6 | pages= 2259-64 | pmid=11115060 | doi=10.1046/j.1523-1755.2000.00410.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11115060 }} </ref><ref name="pmid9556702">{{cite journal| author=Delzell E, Shapiro S| title=A review of epidemiologic studies of nonnarcotic analgesics and chronic renal disease. | journal=Medicine (Baltimore) | year= 1998 | volume= 77 | issue= 2 | pages= 102-21 | pmid=9556702 | doi=10.1097/00005792-199803000-00003 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9556702 }} </ref> | |||
* Further studies are required to assess renal injury and analgesic nephropathy caused by non-phenacetin [[Analgesic|analgesics]] .<ref name="pmid11115060" /> | |||
==References== | ==References== |
Latest revision as of 06:31, 7 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]
Overview
There is a strong association between phenacetin and analgesic nephropathy which has led to the disappearing of classic analgesic nephropathy after the removal of phenacetin from the markets over 30 years ago. Although non-phenacetin analgesics (such as NSAIDs, aspirin and acetaminophen) or their combinations have been reported in some studies as causes to analgesic nephropathy, but there is insufficient evidence that suggests these drugs cause analgesic nephropathy.
Causes
Phenacetin
- There is a strong association between phenacetin and analgesic nephropathy.[1]
- The classic analgesic nephropathy is disappearing after the removal of phenacetin from the markets over 30 years ago.[2]
NSAIDs, aspirin and acetaminophen
- Although non-phenacetin analgesics (such as NSAIDs, aspirin and acetaminophen) and their combinations have been reported in some studies as causes to analgesic nephropathy, but there is insufficient evidence that suggests these drugs cause analgesic nephropathy.[3][4]
- Further studies are required to assess renal injury and analgesic nephropathy caused by non-phenacetin analgesics .[3]
References
- ↑ Yaxley J (2016). "Common Analgesic Agents and Their Roles in Analgesic Nephropathy: A Commentary on the Evidence". Korean J Fam Med. 37 (6): 310–316. doi:10.4082/kjfm.2016.37.6.310. PMC 5122661. PMID 27900067.
- ↑ Mihatsch MJ, Khanlari B, Brunner FP (2006). "Obituary to analgesic nephropathy--an autopsy study". Nephrol Dial Transplant. 21 (11): 3139–45. doi:10.1093/ndt/gfl390. PMID 16891638.
- ↑ 3.0 3.1 Feinstein AR, Heinemann LA, Curhan GC, Delzell E, Deschepper PJ, Fox JM; et al. (2000). "Relationship between nonphenacetin combined analgesics and nephropathy: a review. Ad Hoc Committee of the International Study Group on Analgesics and Nephropathy". Kidney Int. 58 (6): 2259–64. doi:10.1046/j.1523-1755.2000.00410.x. PMID 11115060.
- ↑ Delzell E, Shapiro S (1998). "A review of epidemiologic studies of nonnarcotic analgesics and chronic renal disease". Medicine (Baltimore). 77 (2): 102–21. doi:10.1097/00005792-199803000-00003. PMID 9556702.