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__NOTOC__ | __NOTOC__ | ||
{{B-cell prolymphocytic leukemia}} | {{B-cell prolymphocytic leukemia}} | ||
{{CMG}}; {{AE}}{{Qurrat}},{{CLG}} | |||
== Overview == | == Overview == | ||
Some [[Mutation|mutations]] and [[Genetic|genetic factors]] are thought to play a role in the [[pathogenesis]] of [[B cell|B-cell]] [[prolymphocytic leukemia]]. Some known [[Mutation|mutations]] are: [[p53 gene]] [[mutation]], 11q23 and 13q14 [[Deletion (genetics)|deletions]] and [[Deletion (genetics)|deletions]] from [[chromosome 11]] and [[chromosome 13]]. | |||
B-cell prolymphocytic leukemia | |||
===Genetics=== | |||
*[[Genetic mutations]] like mutation or loss of [[p53]] is thought to play a role.<ref name="pmid9058723">{{cite journal |vauthors=Lens D, De Schouwer PJ, Hamoudi RA, Abdul-Rauf M, Farahat N, Matutes E, Crook T, Dyer MJ, Catovsky D |title=p53 abnormalities in B-cell prolymphocytic leukemia |journal=Blood |volume=89 |issue=6 |pages=2015–23 |date=March 1997 |pmid=9058723 |doi= |url=}}</ref><ref name="pmid9058723">{{cite journal |vauthors=Lens D, De Schouwer PJ, Hamoudi RA, Abdul-Rauf M, Farahat N, Matutes E, Crook T, Dyer MJ, Catovsky D |title=p53 abnormalities in B-cell prolymphocytic leukemia |journal=Blood |volume=89 |issue=6 |pages=2015–23 |date=March 1997 |pmid=9058723 |doi= |url=}}</ref> | |||
*11q23 and 13q14 [[Deletion (genetics)|deletions]] are associated with [[B cell]] [[prolymphocytic leukemia]].<ref name="pmid1381952">{{cite journal |vauthors=Brito-Babapulle V, Ellis J, Matutes E, Oscier D, Khokhar T, MacLennan K, Catovsky D |title=Translocation t(11;14)(q13;q32) in chronic lymphoid disorders |journal=Genes Chromosomes Cancer |volume=5 |issue=2 |pages=158–65 |date=September 1992 |pmid=1381952 |doi= |url=}}</ref><ref name="pmid9595043">{{cite journal |vauthors=Solé F, Woessner S, Espinet B, Lloveras E, Florensa L, Pérez-Losada A, Vilà RM, Besses C, Sans-Sabrafen J |title=Cytogenetic abnormalities in three patients with B-cell prolymphocytic leukemia |journal=Cancer Genet. Cytogenet. |volume=103 |issue=1 |pages=43–5 |date=May 1998 |pmid=9595043 |doi= |url=}}</ref><ref name="pmid10360375">{{cite journal |vauthors=Lens D, Coignet LJ, Brito-Babapulle V, Lima CS, Matutes E, Dyer MJ, Catovsky D |title=B cell prolymphocytic leukaemia (B-PLL) with complex karyotype and concurrent abnormalities of the p53 and c-MYC gene |journal=Leukemia |volume=13 |issue=6 |pages=873–6 |date=June 1999 |pmid=10360375 |doi= |url=}}</ref> | |||
*t(11;14) [[Chromosomal translocation|translocation]] rembles the [[mutation]] of [[mantle cell lymphoma]], which makes it harder for the clinicians to distinguish the two entities.<ref name="pmid15086413">{{cite journal |vauthors=Ruchlemer R, Parry-Jones N, Brito-Babapulle V, Attolico I, Wotherspoon AC, Matutes E, Catovsky D |title=B-prolymphocytic leukaemia with t(11;14) revisited: a splenomegalic form of mantle cell lymphoma evolving with leukaemia |journal=Br. J. Haematol. |volume=125 |issue=3 |pages=330–6 |date=May 2004 |pmid=15086413 |doi=10.1111/j.1365-2141.2004.04913.x |url=}}</ref><ref name="pmid24891323">{{cite journal |vauthors=van der Velden VH, Hoogeveen PG, de Ridder D, Schindler-van der Struijk M, van Zelm MC, Sanders M, Karsch D, Beverloo HB, Lam K, Orfao A, Lugtenburg PJ, Böttcher S, van Dongen JJ, Langerak AW, Kappers-Klunne M, van Lom K |title=B-cell prolymphocytic leukemia: a specific subgroup of mantle cell lymphoma |journal=Blood |volume=124 |issue=3 |pages=412–9 |date=July 2014 |pmid=24891323 |doi=10.1182/blood-2013-10-533869 |url=}}</ref><ref name="pmid26261659">{{cite journal |vauthors=Miao Y, Wang R, Fan L, Qiu H, Wu Y, Chen Y, Xu W, Li J |title=Detection of t(12;14)(p13;q32) in a patient with IGH-CCND1 negative mantle cell lymphoma resembling ultra-high risk chronic lymphocytic leukemia |journal=Int J Clin Exp Pathol |volume=8 |issue=6 |pages=7494–8 |date=2015 |pmid=26261659 |pmc=4525993 |doi= |url=}}</ref> | |||
*It can involve [[Deletion (genetics)|deletions]] from [[chromosome 11]] and [[chromosome 13]].<ref name="pmid10720137">{{cite journal |author=Lens D, Matutes E, Catovsky D, Coignet LJ |title=Frequent deletions at 11q23 and 13q14 in B cell prolymphocytic leukemia (B-PLL) |journal=Leukemia |volume=14 |issue=3 |pages=427-30 |year=2000 |pmid=10720137 |doi=}}</ref> | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
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Latest revision as of 19:23, 8 April 2019
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B-cell prolymphocytic leukemia |
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Differentiating B-cell prolymphocytic leukemia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Qurrat-ul-ain Abid, M.D.[2],Carlos A Lopez, M.D. [3]
Overview
Some mutations and genetic factors are thought to play a role in the pathogenesis of B-cell prolymphocytic leukemia. Some known mutations are: p53 gene mutation, 11q23 and 13q14 deletions and deletions from chromosome 11 and chromosome 13.
Genetics
- Genetic mutations like mutation or loss of p53 is thought to play a role.[1][1]
- 11q23 and 13q14 deletions are associated with B cell prolymphocytic leukemia.[2][3][4]
- t(11;14) translocation rembles the mutation of mantle cell lymphoma, which makes it harder for the clinicians to distinguish the two entities.[5][6][7]
- It can involve deletions from chromosome 11 and chromosome 13.[8]
References
- ↑ 1.0 1.1 Lens D, De Schouwer PJ, Hamoudi RA, Abdul-Rauf M, Farahat N, Matutes E, Crook T, Dyer MJ, Catovsky D (March 1997). "p53 abnormalities in B-cell prolymphocytic leukemia". Blood. 89 (6): 2015–23. PMID 9058723.
- ↑ Brito-Babapulle V, Ellis J, Matutes E, Oscier D, Khokhar T, MacLennan K, Catovsky D (September 1992). "Translocation t(11;14)(q13;q32) in chronic lymphoid disorders". Genes Chromosomes Cancer. 5 (2): 158–65. PMID 1381952.
- ↑ Solé F, Woessner S, Espinet B, Lloveras E, Florensa L, Pérez-Losada A, Vilà RM, Besses C, Sans-Sabrafen J (May 1998). "Cytogenetic abnormalities in three patients with B-cell prolymphocytic leukemia". Cancer Genet. Cytogenet. 103 (1): 43–5. PMID 9595043.
- ↑ Lens D, Coignet LJ, Brito-Babapulle V, Lima CS, Matutes E, Dyer MJ, Catovsky D (June 1999). "B cell prolymphocytic leukaemia (B-PLL) with complex karyotype and concurrent abnormalities of the p53 and c-MYC gene". Leukemia. 13 (6): 873–6. PMID 10360375.
- ↑ Ruchlemer R, Parry-Jones N, Brito-Babapulle V, Attolico I, Wotherspoon AC, Matutes E, Catovsky D (May 2004). "B-prolymphocytic leukaemia with t(11;14) revisited: a splenomegalic form of mantle cell lymphoma evolving with leukaemia". Br. J. Haematol. 125 (3): 330–6. doi:10.1111/j.1365-2141.2004.04913.x. PMID 15086413.
- ↑ van der Velden VH, Hoogeveen PG, de Ridder D, Schindler-van der Struijk M, van Zelm MC, Sanders M, Karsch D, Beverloo HB, Lam K, Orfao A, Lugtenburg PJ, Böttcher S, van Dongen JJ, Langerak AW, Kappers-Klunne M, van Lom K (July 2014). "B-cell prolymphocytic leukemia: a specific subgroup of mantle cell lymphoma". Blood. 124 (3): 412–9. doi:10.1182/blood-2013-10-533869. PMID 24891323.
- ↑ Miao Y, Wang R, Fan L, Qiu H, Wu Y, Chen Y, Xu W, Li J (2015). "Detection of t(12;14)(p13;q32) in a patient with IGH-CCND1 negative mantle cell lymphoma resembling ultra-high risk chronic lymphocytic leukemia". Int J Clin Exp Pathol. 8 (6): 7494–8. PMC 4525993. PMID 26261659.
- ↑ Lens D, Matutes E, Catovsky D, Coignet LJ (2000). "Frequent deletions at 11q23 and 13q14 in B cell prolymphocytic leukemia (B-PLL)". Leukemia. 14 (3): 427–30. PMID 10720137.