Desmoid tumor diagnostic study of choice: Difference between revisions

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{{CMG}} {{AE}}{{S.M.}}
{{CMG}} {{AE}}{{S.M.}}
==Overview==
==Overview==
Diagnostic study of choice for desmoid tumors is biopsy. After biopsy, definitive diagnosis must be established on histopathologic analysis. Electron microscopy is done which shows spindle cells of desmoids appearing as myofibroblasts. Immunohistochemical stains show high nuclear reactivity for beta-catenin accumulation in nucleus.
Definitive [[diagnosis]] of a [[desmoid tumor]] can only be established by [[Histological|histological examination]] of a [[Biopsy|biopsy specimen]]. [[Electron microscopy]] can be done which shows [[spindle cells]] of [[Desmoid tumor|desmoids]] appearing as [[myofibroblasts]].
 


==Diagnostic study of choice==
==Diagnostic study of choice==
*Biopsy is the most important and conclusive diagnostic procedure for desmoid tumor
*[[Biopsy]] is the most important and conclusive [[Diagnostic procedures|diagnostic procedure]] for [[desmoid tumor]]
*After biopsy, definitive diagnosis must be established on histopathologic analysis
*After [[biopsy]], definitive [[diagnosis]] must be established on [[histopathologic]] [[analysis]]
*Electron microscopy is performed to obtain further clarity and confirmation for the diagnosis
*[[Electron microscopy]] is performed to obtain further clarity and confirmation for the [[diagnosis]]
*Spindle cells of desmoid tumors appear to be myofibroblasts on electron microscopy which represents an abnormal proliferation of myofibroblasts, which normally disappear gradually during the later stages of wound healing
*[[Spindle cells]] of [[Desmoid tumor|desmoid tumors]] appear to be [[myofibroblasts]] on [[electron microscopy]] which represents an abnormal [[proliferation]] of [[myofibroblasts]], which normally disappear gradually during the later [[Wound healing phases|stages of wound healing]]
*Immunohistochemical stains are done to look for nuclear accumulation of beta-catenin
*Regardless of the site, 90% of desmoids show nuclear reactivity (has relatively high specificity)

Latest revision as of 17:56, 13 March 2019