ELAV-like protein 1: Difference between revisions

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'''ELAV-like protein 1''' or HuR (human antigen R) is a [[protein]] that in humans is encoded by the ''ELAVL1'' [[gene]].<ref name="pmid8626503">{{cite journal | vauthors = Ma WJ, Cheng S, Campbell C, Wright A, Furneaux H | title = Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein | journal = J Biol Chem | volume = 271 | issue = 14 | pages = 8144–8151 |date=Jun 1996 | pmid = 8626503 | pmc =  | doi =10.1074/jbc.271.14.8144  }}</ref><ref name="pmid9003489">{{cite journal | vauthors = Ma WJ, Furneaux H | title = Localization of the human HuR gene to chromosome 19p13.2 | journal = Hum Genet | volume = 99 | issue = 1 | pages = 32–33 |date=Feb 1997 | pmid = 9003489 | pmc =  | doi =10.1007/s004390050305  }}</ref>
'''ELAV-like protein 1''' or HuR (human antigen R) is a [[protein]] that in humans is encoded by the ''ELAVL1'' [[gene]].<ref name="pmid8626503">{{cite journal | vauthors = Ma WJ, Cheng S, Campbell C, Wright A, Furneaux H | title = Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein | journal = J Biol Chem | volume = 271 | issue = 14 | pages = 8144–8151 |date=Jun 1996 | pmid = 8626503 | pmc =  | doi =10.1074/jbc.271.14.8144  }}</ref><ref name="pmid9003489">{{cite journal | vauthors = Ma WJ, Furneaux H | title = Localization of the human HuR gene to chromosome 19p13.2 | journal = Hum Genet | volume = 99 | issue = 1 | pages = 32–33 |date=Feb 1997 | pmid = 9003489 | pmc =  | doi =10.1007/s004390050305  }}</ref>


The protein encoded by this gene is a member of the [[ELAVL protein family]]. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. One of its best-known functions is to stabilize [[mRNA]]s in order to regulate gene expression.<ref>{{cite web | title = Entrez Gene: ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1994| accessdate = }}</ref>
The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting [[AU-rich element|AU-rich elements]]. One of its best-known functions is to stabilize [[mRNA]]s in order to regulate gene expression.<ref>{{cite web | title = Entrez Gene: ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1994| accessdate = }}</ref>


==See also==
==See also==
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Latest revision as of 09:22, 23 November 2018

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External IDsGeneCards: [1]
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SpeciesHumanMouse
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Wikidata
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ELAV-like protein 1 or HuR (human antigen R) is a protein that in humans is encoded by the ELAVL1 gene.[1][2]

The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. One of its best-known functions is to stabilize mRNAs in order to regulate gene expression.[3]

See also

References

  1. ↑ Ma WJ, Cheng S, Campbell C, Wright A, Furneaux H (Jun 1996). "Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein". J Biol Chem. 271 (14): 8144–8151. doi:10.1074/jbc.271.14.8144. PMID 8626503.
  2. ↑ Ma WJ, Furneaux H (Feb 1997). "Localization of the human HuR gene to chromosome 19p13.2". Hum Genet. 99 (1): 32–33. doi:10.1007/s004390050305. PMID 9003489.
  3. ↑ "Entrez Gene: ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)".

Further reading

This article incorporates text from the United States National Library of Medicine ([2]), which is in the public domain.



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