Kaptin (actin binding protein): Difference between revisions

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{{Infobox_gene}}
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'''Kaptin''' is a [[protein]] that in humans is encoded by the ''KPTN'' [[gene]].<ref name="pmid10099934">{{cite journal |vauthors=Bearer EL, Abraham MT | title = 2E4 (kaptin): a novel actin-associated protein from human blood platelets found in lamellipodia and the tips of the stereocilia of the inner ear | journal = Eur J Cell Biol | volume = 78 | issue = 2 | pages = 117–26 |date=Jul 1999 | pmid = 10099934 | pmc =  | doi =  10.1016/s0171-9335(99)80013-2}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KPTN kaptin (actin binding protein)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11133| accessdate = }}</ref>
'''Kaptin''' is a [[protein]] that in humans is encoded by the ''KPTN'' [[gene]].<ref name="pmid10099934">{{cite journal |vauthors=Bearer EL, Abraham MT | title = 2E4 (kaptin): a novel actin-associated protein from human blood platelets found in lamellipodia and the tips of the stereocilia of the inner ear | journal = Eur J Cell Biol | volume = 78 | issue = 2 | pages = 117–26 |date=Jul 1999 | pmid = 10099934 | pmc =  3376092| doi =  10.1016/s0171-9335(99)80013-2}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KPTN kaptin (actin binding protein)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11133| accessdate = }}</ref>
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Latest revision as of 13:31, 5 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Kaptin is a protein that in humans is encoded by the KPTN gene.[1][2]

Model organisms

Model organisms have been used in the study of KPTN function. A conditional knockout mouse line, called Kptntm1a(EUCOMM)Wtsi[12][13] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[14][15][16]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[10][17] Twenty two tests were carried out on mutant mice and six significant abnormalities were observed.[10] Homozygous mutant mice had hyperalbuminemia, decreased mature B cell numbers and increased susceptibility to bacterial infection. Female mice also had increased body weight, body fat and impaired glucose tolerance.[10]

References

  1. ↑ Bearer EL, Abraham MT (Jul 1999). "2E4 (kaptin): a novel actin-associated protein from human blood platelets found in lamellipodia and the tips of the stereocilia of the inner ear". Eur J Cell Biol. 78 (2): 117–26. doi:10.1016/s0171-9335(99)80013-2. PMC 3376092. PMID 10099934.
  2. ↑ "Entrez Gene: KPTN kaptin (actin binding protein)".
  3. ↑ "Body weight data for Kptn". Wellcome Trust Sanger Institute.
  4. ↑ "Glucose tolerance test data for Kptn". Wellcome Trust Sanger Institute.
  5. ↑ "DEXA data for Kptn". Wellcome Trust Sanger Institute.
  6. ↑ "Clinical chemistry data for Kptn". Wellcome Trust Sanger Institute.
  7. ↑ "Peripheral blood lymphocytes data for Kptn". Wellcome Trust Sanger Institute.
  8. ↑ "Salmonella infection data for Kptn". Wellcome Trust Sanger Institute.
  9. ↑ "Citrobacter infection data for Kptn". Wellcome Trust Sanger Institute.
  10. ↑ 10.0 10.1 10.2 10.3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  11. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  12. ↑ "International Knockout Mouse Consortium".
  13. ↑ "Mouse Genome Informatics".
  14. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  15. ↑ Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  16. ↑ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  17. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading


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