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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
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'''Solute carrier family 13 member 3''' also called '''sodium-dependent dicarboxylate transporter''' (NaDC3) is a [[protein]] that in humans is encoded by the ''SLC13A3'' [[gene]].<ref name="pmid10794676">{{cite journal | vauthors = Wang H, Fei YJ, Kekuda R, Yang-Feng TL, Devoe LD, Leibach FH, Prasad PD, Ganapathy V | title = Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter | journal = Am J Physiol Cell Physiol | volume = 278 | issue = 5 | pages = C1019–30 |date=Jun 2000 | pmid = 10794676 | pmc =  | doi =  }}</ref><ref name="pmid10992006">{{cite journal | vauthors = Huang W, Wang H, Kekuda R, Fei YJ, Friedrich A, Wang J, Conway SJ, Cameron RS, Leibach FH, Ganapathy V | title = Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain | journal = J Pharmacol Exp Ther | volume = 295 | issue = 1 | pages = 392–403 |date=Nov 2000 | pmid = 10992006 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64849| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
| HGNCid = 14430
| Symbol = SLC13A3
| AltSymbols =; NADC3; SDCT2
| OMIM = 606411
| ECnumber =
| Homologene = 11266
| MGIid = 2149635
| GeneAtlas_image1 = PBB_GE_SLC13A3_205243_at_tn.png
  | GeneAtlas_image2 = PBB_GE_SLC13A3_205244_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0015362 |text = high affinity sodium:dicarboxylate symporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0006835 |text = dicarboxylic acid transport}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 64849
    | Hs_Ensembl = ENSG00000158296
    | Hs_RefseqProtein = NP_001011554
    | Hs_RefseqmRNA = NM_001011554
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 44619870
    | Hs_GenLoc_end = 44732185
    | Hs_Uniprot = Q8WWT9
    | Mm_EntrezGene = 114644
    | Mm_Ensembl = ENSMUSG00000018459
    | Mm_RefseqmRNA = NM_054055
    | Mm_RefseqProtein = NP_473396
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 165096492
    | Mm_GenLoc_end = 165164402
    | Mm_Uniprot = Q3UUJ6
  }}
}}
'''Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3''', also known as '''SLC13A3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64849| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.<ref name="entrez">{{cite web | title = Entrez Gene: SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64849| accessdate = }}</ref>
| summary_text = Mammalian sodium-dicarboxylate [[cotransporter]]s transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.<ref name="entrez">{{cite web | title = Entrez Gene: SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64849| accessdate = }}</ref>
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Markovich D, Murer H |title=The SLC13 gene family of sodium sulphate/carboxylate cotransporters. |journal=Pflügers Arch. |volume=447 |issue= 5 |pages= 594–602 |year= 2004 |pmid= 12915942 |doi= 10.1007/s00424-003-1128-6 }}
| citations =
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | author=Markovich D, Murer H |title=The SLC13 gene family of sodium sulphate/carboxylate cotransporters. |journal=Pflugers Arch. |volume=447 |issue= 5 |pages= 594-602 |year= 2004 |pmid= 12915942 |doi= 10.1007/s00424-003-1128-6 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Wang H, Fei YJ, Kekuda R, ''et al.'' |title=Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter. |journal=Am. J. Physiol., Cell Physiol. |volume=278 |issue= 5 |pages= C1019-30 |year= 2000 |pmid= 10794676 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Huang W, Wang H, Kekuda R, ''et al.'' |title=Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain. |journal=J. Pharmacol. Exp. Ther. |volume=295 |issue= 1 |pages= 392-403 |year= 2000 |pmid= 10992006 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | vauthors=Burckhardt BC, Lorenz J, Kobbe C, Burckhardt G |title=Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions. |journal=Am. J. Physiol. Renal Physiol. |volume=288 |issue= 4 |pages= F792–9 |year= 2005 |pmid= 15561973 |doi= 10.1152/ajprenal.00360.2004 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Bai X, Chen X, Feng Z, etal |title=Identification of basolateral membrane targeting signal of human sodium-dependent dicarboxylate transporter 3. |journal=J. Cell. Physiol. |volume=206 |issue= 3 |pages= 821–30 |year= 2006 |pmid= 16331647 |doi= 10.1002/jcp.20553 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Burckhardt BC, Lorenz J, Kobbe C, Burckhardt G |title=Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions. |journal=Am. J. Physiol. Renal Physiol. |volume=288 |issue= 4 |pages= F792-9 |year= 2005 |pmid= 15561973 |doi= 10.1152/ajprenal.00360.2004 }}
*{{cite journal | author=Bai X, Chen X, Feng Z, ''et al.'' |title=Identification of basolateral membrane targeting signal of human sodium-dependent dicarboxylate transporter 3. |journal=J. Cell. Physiol. |volume=206 |issue= 3 |pages= 821-30 |year= 2006 |pmid= 16331647 |doi= 10.1002/jcp.20553 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{Membrane transport proteins|bg|bg1}}
 
[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 07:20, 10 January 2019

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.[1][2][3]

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.[3]

See also

References

  1. ↑ Wang H, Fei YJ, Kekuda R, Yang-Feng TL, Devoe LD, Leibach FH, Prasad PD, Ganapathy V (Jun 2000). "Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter". Am J Physiol Cell Physiol. 278 (5): C1019–30. PMID 10794676.
  2. ↑ Huang W, Wang H, Kekuda R, Fei YJ, Friedrich A, Wang J, Conway SJ, Cameron RS, Leibach FH, Ganapathy V (Nov 2000). "Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain". J Pharmacol Exp Ther. 295 (1): 392–403. PMID 10992006.
  3. ↑ 3.0 3.1 "Entrez Gene: SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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