CLK3 (gene): Difference between revisions

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Latest revision as of 12:44, 9 January 2019

Dual specificity protein kinase CLK3 is an enzyme that in humans is encoded by the CLK3 gene.^[1]^[2] The CLK3 gene encodes a serine/threonine type protein kinase with a non-conserved N-terminal domain. A long and short isoform (phclk3 and pclk3/152) result from alternative splicing and coexist in different tissues. Isoform phclk3/152 lacks the kinase domain.^[3]

References

↑ Hanes J, von der Kammer H, Klaudiny J, Scheit KH (Jan 1995). "Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases". J Mol Biol. 244 (5): 665–72. doi:10.1006/jmbi.1994.1763. PMID 7990150.
↑ Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L (Dec 1998). "Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Hum Genet. 103 (4): 523–4. doi:10.1007/s004390050861. PMID 9856501.
↑ "Entrez Gene: CLK3 CDC-like kinase 3".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Duncan PI, Stojdl DF, Marius RM, et al. (1998). "The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing". Exp. Cell Res. 241 (2): 300–8. doi:10.1006/excr.1998.4083. PMID 9637771.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.

External links

Clk dual-specificity kinases at the US National Library of Medicine Medical Subject Headings (MeSH)
Human CLK3 genome location and CLK3 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[pmid7990150-1] Hanes J, von der Kammer H, Klaudiny J, Scheit KH (Jan 1995). "Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases". J Mol Biol. 244 (5): 665–72. doi:10.1006/jmbi.1994.1763. PMID 7990150.

[pmid9856501-2] Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L (Dec 1998). "Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Hum Genet. 103 (4): 523–4. doi:10.1007/s004390050861. PMID 9856501.

[entrez-3] "Entrez Gene: CLK3 CDC-like kinase 3".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
+{{Infobox_gene}}
+'''Dual specificity protein kinase CLK3''' is an [[enzyme]] that in humans is encoded by the ''CLK3'' [[gene]].<ref name="pmid7990150">{{cite journal | vauthors = Hanes J, von der Kammer H, Klaudiny J, Scheit KH | title = Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases | journal = J Mol Biol | volume = 244 | issue = 5 | pages = 665–72 |date=Jan 1995 | pmid = 7990150 | pmc =  | doi = 10.1006/jmbi.1994.1763 }}</ref><ref name="pmid9856501">{{cite journal | vauthors = Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L | title = Chromosomal mapping of three human LAMMER protein-kinase-encoding genes | journal = Hum Genet | volume = 103 | issue = 4 | pages = 523–4 |date=Dec 1998 | pmid = 9856501 | pmc =  | doi =10.1007/s004390050861  }}</ref>
+The CLK3 gene encodes a [[serine/threonine-specific protein kinase|serine/threonine]] type [[protein]] [[kinase]] with a non-conserved [[N-terminus|N-terminal]] [[protein domain|domain]]. A long and short isoform (phclk3 and pclk3/152) result from [[alternative splicing]] and coexist in different tissues. Isoform phclk3/152 lacks the kinase domain.<ref name="entrez">{{cite web | title = Entrez Gene: CLK3 CDC-like kinase 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1198| accessdate = }}</ref>
+==References==
+{{reflist}}
+==Further reading==
+{{refbegin | 2}}
+{{PBB_Further_reading
+| citations =
+*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
+*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |display-authors=etal}}
+*{{cite journal  | vauthors=Duncan PI, Stojdl DF, Marius RM |title=The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing |journal=Exp. Cell Res. |volume=241 |issue= 2 |pages= 300–8 |year= 1998 |pmid= 9637771 |doi= 10.1006/excr.1998.4083 |display-authors=etal}}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
+*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
+*{{cite journal  | vauthors=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8  | pmc=395752 }}
+*{{cite journal  | vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |display-authors=etal}}
+*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
+*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
+*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
+*{{cite journal  | vauthors=Wissing J, Jänsch L, Nimtz M |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry |journal=Mol. Cell. Proteomics |volume=6 |issue= 3 |pages= 537–47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200 |display-authors=etal}}
+}}
+{{refend}}
+{{PDB Gallery|geneid=1198}}
+==External links==
+* {{MeshName|Clk+dual-specificity+kinases|3=Clk dual-specificity kinases}}
+* {{UCSC gene info|CLK3}}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
 {{PBB_Controls
@@ Line 4: / Line 34: @@
 | require_manual_inspection = no
 | update_protein_box = yes
-| update_summary = yes
+| update_summary = no
 | update_citations = yes
 }}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_CLK3_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2eu9.
- | PDB = {{PDB2|2eu9}}, {{PDB2|2exe}}
- | Name = CDC-like kinase 3
- | HGNCid = 2071
- | Symbol = CLK3
- | AltSymbols =; FLJ22858
- | OMIM = 602990
- | ECnumber =
- | Homologene = 37869
- | MGIid = 1098670
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 1198
-    | Hs_Ensembl =
-    | Hs_RefseqProtein = NP_001283
-    | Hs_RefseqmRNA = NM_001292
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr =
-    | Hs_GenLoc_start =
-    | Hs_GenLoc_end =
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 102414
-    | Mm_Ensembl = ENSMUSG00000032316
-    | Mm_RefseqmRNA = NM_007713
-    | Mm_RefseqProtein = NP_031739
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 9
-    | Mm_GenLoc_start = 57548848
-    | Mm_GenLoc_end = 57563997
-    | Mm_Uniprot = Q3TJU0
-  }}
-}}
-'''CDC-like kinase 3''', also known as '''CLK3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLK3 CDC-like kinase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1198| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = CLK3 encodes a serine/threonine type protein kinase with a non-conserved N-terminal domain. A long and short isoform (phclk3 and pclk3/152) result from alternative splicing and coexist in different tissues. Isoform phclk3/152 lacks the kinase domain.<ref name="entrez">{{cite web | title = Entrez Gene: CLK3 CDC-like kinase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1198| accessdate = }}</ref>
-}}
-==References==
-{{reflist|2}}
-==Further reading==
-{{refbegin | 2}}
-{{PBB_Further_reading
-| citations =
-*{{cite journal  | author=Hanes J, von der Kammer H, Klaudiny J, Scheit KH |title=Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases. |journal=J. Mol. Biol. |volume=244 |issue= 5 |pages= 665-72 |year= 1995 |pmid= 7990150 |doi= 10.1006/jmbi.1994.1763 }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
-*{{cite journal  | author=Duncan PI, Stojdl DF, Marius RM, ''et al.'' |title=The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. |journal=Exp. Cell Res. |volume=241 |issue= 2 |pages= 300-8 |year= 1998 |pmid= 9637771 |doi= 10.1006/excr.1998.4083 }}
-*{{cite journal  | author=Talmadge CB, Finkernagel S, Sumegi J, ''et al.'' |title=Chromosomal mapping of three human LAMMER protein-kinase-encoding genes. |journal=Hum. Genet. |volume=103 |issue= 4 |pages= 523-4 |year= 1998 |pmid= 9856501 |doi=  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8 }}
-*{{cite journal  | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
-*{{cite journal  | author=Wissing J, Jänsch L, Nimtz M, ''et al.'' |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. |journal=Mol. Cell Proteomics |volume=6 |issue= 3 |pages= 537-47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200 }}
-}}
-{{refend}}
-{{protein-stub}}
+{{gene-15-stub}}
-{{WikiDoc Sources}}

CLK3 (gene): Difference between revisions

Latest revision as of 12:44, 9 January 2019

References

Further reading

External links

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