Paroxysmal nocturnal hemoglobinuria natural history, complications and prognosis: Difference between revisions
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{{ Paroxysmal nocturnal hemoglobinuria | {{Paroxysmal nocturnal hemoglobinuria}} | ||
{{CMG}}; {{AE}} {{AEL}} | |||
==Overview== | ==Overview== | ||
If left untreated, patients with paroxysmal nocturnal hemoglobinuria may progress to develop [[thrombosis]] which is a main cause of death in PNH. Common complications include intracranial thrombosis, [[splenic vein thrombosis]], and [[portal vein thrombosis]]. Prognosis of paroxysmal nocturnal hemoglobinuria is good as long as anti-complemant therapy [[eculizumab]] is taken regularly. | |||
==Natural History, Complications, and Prognosis== | |||
==Natural History== | ===Natural History=== | ||
*If left untreated, patients with paroxysmal nocturnal hemoglobinuria may progress to develop [[thrombosis]] which is a main cause of death in PNH. | |||
*PNH is associated with high morbidity and mortality rate if appropriate treatment is not administrated regularly. | |||
==Complications== | ===Complications=== | ||
*Common complications of paroxysmal nocturnal hemoglobinuria include: | |||
** Intracranial thrombosis | |||
** [[Splenic vein thrombosis]] | |||
** [[Portal vein thrombosis]] | |||
==Prognosis== | ===Prognosis=== | ||
*Prognosis of paroxysmal nocturnal hemoglobinuria is good as long as anti-complemant therapy eculizumab is taken regularly. | |||
*[[Eculizumab]] has shown decrease in the risk of thrombosis which is a main cause of death in patients with PNH. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category: (name of the system)]] |
Latest revision as of 00:12, 1 November 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
If left untreated, patients with paroxysmal nocturnal hemoglobinuria may progress to develop thrombosis which is a main cause of death in PNH. Common complications include intracranial thrombosis, splenic vein thrombosis, and portal vein thrombosis. Prognosis of paroxysmal nocturnal hemoglobinuria is good as long as anti-complemant therapy eculizumab is taken regularly.
Natural History, Complications, and Prognosis
Natural History
- If left untreated, patients with paroxysmal nocturnal hemoglobinuria may progress to develop thrombosis which is a main cause of death in PNH.
- PNH is associated with high morbidity and mortality rate if appropriate treatment is not administrated regularly.
Complications
- Common complications of paroxysmal nocturnal hemoglobinuria include:
- Intracranial thrombosis
- Splenic vein thrombosis
- Portal vein thrombosis
Prognosis
- Prognosis of paroxysmal nocturnal hemoglobinuria is good as long as anti-complemant therapy eculizumab is taken regularly.
- Eculizumab has shown decrease in the risk of thrombosis which is a main cause of death in patients with PNH.