Anemia of chronic disease natural history, complications and prognosis: Difference between revisions
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{{Anemia of chronic disease}} | {{Anemia of chronic disease}} | ||
{{CMG}} | {{CMG}} {{AE}} {{OK}} | ||
==Overview== | ==Overview== | ||
Potentially life-threatening complications include c[[Congestive heart failure|ongestive heart failure]], [[Angina]], [[Arrhythmia|arrhythmia]], m[[Myocardial infarction|yocardial infarction and]] high-output [[heart failure|heart failure.]] If left untreated, [[anemia of chronic disease]] usually manifests as [[congestive heart failure]], [[angina]], [[arrhythmia]], [[myocardial infarction]] and high-output [[heart failure]].The [[anemia]] will improve when the disease that is causing it is successfully treated. | |||
==Natural History== | ==Natural History== | ||
If left untreated, [[anemia of chronic disease]] usually manifests as [[congestive heart failure]], [[angina]], [[arrhythmia]], [[myocardial infarction]] and high-output [[heart failure]]. | |||
==Complications== | ==Complications== | ||
===== Potentially life-threatening complications ===== | |||
* [[Congestive heart failure]] [[Angina]] | |||
* [[Arrhythmia]] [[Myocardial infarction]] | |||
Potentially life-threatening complications | |||
[[Congestive heart failure]] [[Angina]] | |||
[[Arrhythmia]] [[Myocardial infarction | |||
* High-output [[heart failure]] | |||
'''Decreased oxygen delivery'''<ref name="pmid9438742">{{cite journal |vauthors=Weiskopf RB, Viele MK, Feiner J, Kelley S, Lieberman J, Noorani M, Leung JM, Fisher DM, Murray WR, Toy P, Moore MA |title=Human cardiovascular and metabolic response to acute, severe isovolemic anemia |journal=JAMA |volume=279 |issue=3 |pages=217–21 |date=January 1998 |pmid=9438742 |doi= |url=}}</ref> | |||
* Exertional [[dyspnea]] [[Dyspnea]] at rest | |||
* [[Fatigue]] Hyperdynamic signs like bounding [[pulses]], [[palpitations]], and a roaring [[Pulsatile Flow|pulsatile]] sound in the ears | |||
* [[Lethargy]], [[confusion]] | |||
'''Hypovolemia''' | |||
* Easy [[fatigability]] [[Lassitude]] | |||
* [[Muscle cramps]] [[Postural dizziness]] | |||
* [[Lethargy]] [[Syncope]] | |||
'''Exacerbation of thrombocytopenic bleeding''' <ref name="pmid28679741">{{cite journal |vauthors=Uhl L, Assmann SF, Hamza TH, Harrison RW, Gernsheimer T, Slichter SJ |title=Laboratory predictors of bleeding and the effect of platelet and RBC transfusions on bleeding outcomes in the PLADO trial |journal=Blood |volume=130 |issue=10 |pages=1247–1258 |date=September 2017 |pmid=28679741 |pmc=5606003 |doi=10.1182/blood-2017-01-757930 |url=}}</ref> | * Persistent [[hypotension]] [[Shock]], and death | ||
* '''Exacerbation of thrombocytopenic bleeding''' <ref name="pmid28679741">{{cite journal |vauthors=Uhl L, Assmann SF, Hamza TH, Harrison RW, Gernsheimer T, Slichter SJ |title=Laboratory predictors of bleeding and the effect of platelet and RBC transfusions on bleeding outcomes in the PLADO trial |journal=Blood |volume=130 |issue=10 |pages=1247–1258 |date=September 2017 |pmid=28679741 |pmc=5606003 |doi=10.1182/blood-2017-01-757930 |url=}}</ref> | |||
A correlation has been observed between severe [[anemia]] and increased [[bleeding]] risk | * A correlation has been observed between severe [[anemia]] and increased [[bleeding]] risk | ||
==Prognosis== | ==Prognosis== | ||
The anemia will improve when the disease that is causing it is successfully treated. | The [[anemia]] will improve when the disease that is causing it is successfully treated. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} |
Latest revision as of 19:47, 9 October 2018
Anemia of chronic disease Microchapters | |
Differentiating Anemia of chronic disease from other Diseases | |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Omer Kamal, M.D.[2]
Overview
Potentially life-threatening complications include congestive heart failure, Angina, arrhythmia, myocardial infarction and high-output heart failure. If left untreated, anemia of chronic disease usually manifests as congestive heart failure, angina, arrhythmia, myocardial infarction and high-output heart failure.The anemia will improve when the disease that is causing it is successfully treated.
Natural History
If left untreated, anemia of chronic disease usually manifests as congestive heart failure, angina, arrhythmia, myocardial infarction and high-output heart failure.
Complications
Potentially life-threatening complications
- High-output heart failure
Decreased oxygen delivery[1]
- Exertional dyspnea Dyspnea at rest
- Fatigue Hyperdynamic signs like bounding pulses, palpitations, and a roaring pulsatile sound in the ears
- Lethargy, confusion
Hypovolemia
- Persistent hypotension Shock, and death
- Exacerbation of thrombocytopenic bleeding [2]
Prognosis
The anemia will improve when the disease that is causing it is successfully treated.
References
- ↑ Weiskopf RB, Viele MK, Feiner J, Kelley S, Lieberman J, Noorani M, Leung JM, Fisher DM, Murray WR, Toy P, Moore MA (January 1998). "Human cardiovascular and metabolic response to acute, severe isovolemic anemia". JAMA. 279 (3): 217–21. PMID 9438742.
- ↑ Uhl L, Assmann SF, Hamza TH, Harrison RW, Gernsheimer T, Slichter SJ (September 2017). "Laboratory predictors of bleeding and the effect of platelet and RBC transfusions on bleeding outcomes in the PLADO trial". Blood. 130 (10): 1247–1258. doi:10.1182/blood-2017-01-757930. PMC 5606003. PMID 28679741.