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| == Splenomegaly differential: ==
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| {| class="wikitable"
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| ! rowspan="4" |Category
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| ! colspan="2" rowspan="4" |Disease
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| ! rowspan="4" |Etiology
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| ! colspan="12" |'''Clinical manifestations'''
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| ! colspan="10" |'''Para−clinical findings'''
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| ! rowspan="4" |'''Gold standard'''
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| ! rowspan="4" |Associated findings
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| |-
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| ! rowspan="3" |'''Demography'''
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| ! rowspan="3" |History
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| ! colspan="5" |'''Symptoms'''
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| ! colspan="5" |Signs
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| ! colspan="9" |Lab Findings
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| ! rowspan="3" |Imaging
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| |-
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| ! rowspan="2" |Fever
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| ! rowspan="2" |Fatigue
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| ! rowspan="2" |Weight loss
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| ! rowspan="2" |SOB
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| ! rowspan="2" |Bleeding
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| ! rowspan="2" |BP
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| ! rowspan="2" |JVP
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| ! rowspan="2" |Jaundice
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| ! rowspan="2" |Ascites
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| ! rowspan="2" |Other
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| ! colspan="3" |CBC
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| ! rowspan="2" |PS
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| ! rowspan="2" |Iron
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| ! rowspan="2" |LFT
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| ! rowspan="2" |PT/PTT
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| ! rowspan="2" |BUN/Cr
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| ! rowspan="2" |UA
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| |-
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| !WBC
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| !Hb
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| !Plt
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| |'''Congestive'''
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| |Cirrhosis
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| |-
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| |CHF
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| |-
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| |Thrombosis of portal, hepatic, or splenic veins
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| |'''Malignancy'''
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| |Lymphoma
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| |-
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| |Leukemias
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| |-
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| |Polycythemia vera
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| |-
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| |Multiple myeloma
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| |-
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| |Essential thrombocythemia
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| |Primary myelofibrosis
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| |Primary splenic tumors
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| |Metastatic solid tumors
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| |-
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| |'''Infection'''
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| |Viral
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| |Hepatitis, infectious mononucleosis, cytomegalovirus
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| |-
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| |Bacterial
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| |Salmonella, Brucella, tuberculosis
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| |-
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| |Parasitic
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| |Malaria, schistosomiasis, toxoplasmosis
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| |Kala-azar (visceral leishmaniasis)
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| |Infective endocarditis
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| |Fungal
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| |Inflammation
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| |Sarcoid
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| |Serum sickness
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| |Systemic lupus erythematosus
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| |Felty syndrome
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| |Infiltrative
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| |Gaucher disease
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| |-
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| |Niemann-Pick disease
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| |-
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| |Amyloidosis
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| |-
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| |Langerhans cell histiocytosis
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| |-
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| |Hemophagocytic lymphohistiocytosis
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| |-
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| |Rosai-Dorfman disease
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| |Hematologic (hypersplenic) states
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| |Hemolytic anemia
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| |Sickle cell disease
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| |-
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| |Granulocyte colony-stimulating factor
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| |Category
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| |Disease
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| |Etiology
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| |'''Demography'''
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| |History
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| |Fever
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| |Fatigue
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| |Weight loss
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| |SOB
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| |Bleeding
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| |BP
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| |JVP
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| |Jaundice
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| |Ascites
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| |Other
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| |WBC
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| |Hb
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| |Plt
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| |PS
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| |Iron
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| |LFT
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| |PT/PTT
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| |BUN/Cr
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| |UA
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| |Imaging
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| |'''Gold standard'''
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| |Associated findings
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| |}
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