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== Overview ==
== Overview ==
In 1952, Vittorio Staudacher was the first to perform a liver transplantation (LT) in a canine species. In 1968, Roy Calne and Roger Williams reported 5 cases of liver transplant, discussing the technical problems by details. In 1984, Bismuth reported the first left-lobe LT in a child. Now, there are hundreds of liver transplant centres in over 80 countries.


== Liver transplantation historical perspective ==
== Liver transplantation historical perspective ==
* In 1952, Vittorio Staudacher was the first to perform a liver transplantation (LT) in a large animal model, a canine species.<ref name="pmid22458426">{{cite journal| author=Busuttil RW, De Carlis LG, Mihaylov PV, Gridelli B, Fassati LR, Starzl TE| title=The first report of orthotopic liver transplantation in the Western world. | journal=Am J Transplant | year= 2012 | volume= 12 | issue= 6 | pages= 1385-7 | pmid=22458426 | doi=10.1111/j.1600-6143.2012.04026.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22458426  }}</ref>  
* In 1952, Vittorio Staudacher was the first to perform a liver transplantation (LT) in a canine species.<ref name="pmid22458426">{{cite journal| author=Busuttil RW, De Carlis LG, Mihaylov PV, Gridelli B, Fassati LR, Starzl TE| title=The first report of orthotopic liver transplantation in the Western world. | journal=Am J Transplant | year= 2012 | volume= 12 | issue= 6 | pages= 1385-7 | pmid=22458426 | doi=10.1111/j.1600-6143.2012.04026.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22458426  }}</ref>  
* Two years later, Jack Cannon was credited with the first animal orthotopic LT.<ref name="pmid23752825">{{cite journal| author=Zarrinpar A, Busuttil RW| title=Liver transplantation: past, present and future. | journal=Nat Rev Gastroenterol Hepatol | year= 2013 | volume= 10 | issue= 7 | pages= 434-40 | pmid=23752825 | doi=10.1038/nrgastro.2013.88 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23752825 }}</ref>  
* Thomas Starzl published the first three attempts at human LT. In 1967 the procedure resulted in the first extended survival.<ref name="pmid14100514">{{cite journal| author=STARZL TE, MARCHIORO TL, VONKAULLA KN, HERMANN G, BRITTAIN RS, WADDELL WR| title=HOMOTRANSPLANTATION OF THE LIVER IN HUMANS. | journal=Surg Gynecol Obstet | year= 1963 | volume= 117 | issue= | pages= 659-76 | pmid=14100514 | doi= | pmc=2634660 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14100514 }}</ref>  
* Thomas Starzl published the first three attempts at human LT, but it was not until 1967 that the procedure resulted in an extended survival.<ref name="pmid14100514">{{cite journal| author=STARZL TE, MARCHIORO TL, VONKAULLA KN, HERMANN G, BRITTAIN RS, WADDELL WR| title=HOMOTRANSPLANTATION OF THE LIVER IN HUMANS. | journal=Surg Gynecol Obstet | year= 1963 | volume= 117 | issue= | pages= 659-76 | pmid=14100514 | doi= | pmc=2634660 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14100514 }}</ref>  
* In 1968, Roy Calne and Roger Williams reported 5 cases of liver transplant, discussing the technical problems by details.<ref name="pmid23752825">{{cite journal| author=Zarrinpar A, Busuttil RW| title=Liver transplantation: past, present and future. | journal=Nat Rev Gastroenterol Hepatol | year= 2013 | volume= 10 | issue= 7 | pages= 434-40 | pmid=23752825 | doi=10.1038/nrgastro.2013.88 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23752825 }}</ref>  
* In 1968, Roy Calne and Roger Williams reported 5 cases of liver transplant, detailing the technical difficulties encountered.


* The introduction of cyclosporine in the late 1970s as part of the immunosuppressive regimen in organ transplantation permitted less toxicity and the prevention of rejection and severe opportunistic infections when compared to azathioprine.<ref name="pmid91781">{{cite journal| author=Calne RY, Rolles K, White DJ, Thiru S, Evans DB, McMaster P et al.| title=Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers. | journal=Lancet | year= 1979 | volume= 2 | issue= 8151 | pages= 1033-6 | pmid=91781 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=91781  }}</ref>
* In the late 1970s, the introduction of [[cyclosporine]]  as part of the [[Immunosuppression|immunosuppressive]] regimen in organ transplantation permitted prevention of rejection and severe opportunistic infections when compared to [[azathioprine]].<ref name="pmid91781">{{cite journal| author=Calne RY, Rolles K, White DJ, Thiru S, Evans DB, McMaster P et al.| title=Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers. | journal=Lancet | year= 1979 | volume= 2 | issue= 8151 | pages= 1033-6 | pmid=91781 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=91781  }}</ref>
* In 1984, Bismuth reported the first left-lobe LT in a child, and in 1988, Pichlmayr performed the first split-LT in Germany.
* In 1984, Bismuth reported the first left-lobe LT in a child.
* In 1988, Pichlmayr performed the first split-LT in Germany.
* In 1985, Silvano Raia described the first attempt at a living donor graft in a child.<ref name="pmid2336076">{{cite journal| author=Strong RW, Lynch SV, Ong TH, Matsunami H, Koido Y, Balderson GA| title=Successful liver transplantation from a living donor to her son. | journal=N Engl J Med | year= 1990 | volume= 322 | issue= 21 | pages= 1505-7 | pmid=2336076 | doi=10.1056/NEJM199005243222106 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2336076  }}</ref>
* In 1985, Silvano Raia described the first attempt at a living donor graft in a child.<ref name="pmid2336076">{{cite journal| author=Strong RW, Lynch SV, Ong TH, Matsunami H, Koido Y, Balderson GA| title=Successful liver transplantation from a living donor to her son. | journal=N Engl J Med | year= 1990 | volume= 322 | issue= 21 | pages= 1505-7 | pmid=2336076 | doi=10.1056/NEJM199005243222106 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2336076  }}</ref>
* Since the nineties, the field of LT has witnessed a huge expansion of the number of institutions performing the procedure, and today, there are hundreds of liver transplant centres in over 80 countries.
* Since the nineties, there are hundreds of liver transplant centres in over 80 countries.


==References==
==References==
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{{Reflist|2}}
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Latest revision as of 16:09, 21 December 2017

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]

Liver trasnsplantation Microchapters

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Overview

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Overview

In 1952, Vittorio Staudacher was the first to perform a liver transplantation (LT) in a canine species. In 1968, Roy Calne and Roger Williams reported 5 cases of liver transplant, discussing the technical problems by details. In 1984, Bismuth reported the first left-lobe LT in a child. Now, there are hundreds of liver transplant centres in over 80 countries.

Liver transplantation historical perspective

  • In 1952, Vittorio Staudacher was the first to perform a liver transplantation (LT) in a canine species.[1]
  • Thomas Starzl published the first three attempts at human LT. In 1967 the procedure resulted in the first extended survival.[2]
  • In 1968, Roy Calne and Roger Williams reported 5 cases of liver transplant, discussing the technical problems by details.[3]
  • In the late 1970s, the introduction of cyclosporine as part of the immunosuppressive regimen in organ transplantation permitted prevention of rejection and severe opportunistic infections when compared to azathioprine.[4]
  • In 1984, Bismuth reported the first left-lobe LT in a child.
  • In 1988, Pichlmayr performed the first split-LT in Germany.
  • In 1985, Silvano Raia described the first attempt at a living donor graft in a child.[5]
  • Since the nineties, there are hundreds of liver transplant centres in over 80 countries.

References

  1. Busuttil RW, De Carlis LG, Mihaylov PV, Gridelli B, Fassati LR, Starzl TE (2012). "The first report of orthotopic liver transplantation in the Western world". Am J Transplant. 12 (6): 1385–7. doi:10.1111/j.1600-6143.2012.04026.x. PMID 22458426.
  2. STARZL TE, MARCHIORO TL, VONKAULLA KN, HERMANN G, BRITTAIN RS, WADDELL WR (1963). "HOMOTRANSPLANTATION OF THE LIVER IN HUMANS". Surg Gynecol Obstet. 117: 659–76. PMC 2634660. PMID 14100514.
  3. Zarrinpar A, Busuttil RW (2013). "Liver transplantation: past, present and future". Nat Rev Gastroenterol Hepatol. 10 (7): 434–40. doi:10.1038/nrgastro.2013.88. PMID 23752825.
  4. Calne RY, Rolles K, White DJ, Thiru S, Evans DB, McMaster P; et al. (1979). "Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases, and 2 livers". Lancet. 2 (8151): 1033–6. PMID 91781.
  5. Strong RW, Lynch SV, Ong TH, Matsunami H, Koido Y, Balderson GA (1990). "Successful liver transplantation from a living donor to her son". N Engl J Med. 322 (21): 1505–7. doi:10.1056/NEJM199005243222106. PMID 2336076.

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