SYTL4: Difference between revisions

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{{Underlinked|date=June 2016}}
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{{Infobox_gene}}
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'''Synaptotagmin-like protein 4''' is a [[protein]] that in humans is encoded by the ''SYTL4'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SYTL4 synaptotagmin-like 4 (granuphilin-a)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=94121| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_SYTL4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2csz.
| PDB = {{PDB2|2csz}}
| Name = Synaptotagmin-like 4 (granuphilin-a)
| HGNCid = 15588
| Symbol = SYTL4
| AltSymbols =; DKFZp451P0116; FLJ40960
| OMIM = 
| ECnumber = 
| Homologene = 8454
| MGIid = 1351606
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005543 |text = phospholipid binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0017137 |text = Rab GTPase binding}} {{GNF_GO|id=GO:0042043 |text = neurexin binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0019897 |text = extrinsic to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006887 |text = exocytosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 94121
    | Hs_Ensembl = ENSG00000102362
    | Hs_RefseqProtein = NP_542775
    | Hs_RefseqmRNA = NM_080737
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 99816144
    | Hs_GenLoc_end = 99873764
    | Hs_Uniprot = Q96C24
    | Mm_EntrezGene = 27359
    | Mm_Ensembl = ENSMUSG00000031255
    | Mm_RefseqmRNA = NM_013757
    | Mm_RefseqProtein = NP_038785
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 129282733
    | Mm_GenLoc_end = 129328133
    | Mm_Uniprot = Q549X6
  }}
}}
'''Synaptotagmin-like 4 (granuphilin-a)''', also known as '''SYTL4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SYTL4 synaptotagmin-like 4 (granuphilin-a)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=94121| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Wang J, Takeuchi T, Yokota H, Izumi T |title=Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells. |journal=J. Biol. Chem. |volume=274 |issue= 40 |pages= 28542-8 |year= 1999 |pmid= 10497219 |doi=  }}
*{{cite journal  | vauthors=Wang J, Takeuchi T, Yokota H, Izumi T |title=Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells. |journal=J. Biol. Chem. |volume=274 |issue= 40 |pages= 28542–8 |year= 1999 |pmid= 10497219 |doi=10.1074/jbc.274.40.28542 }}
*{{cite journal  | author=Kuroda TS, Fukuda M, Ariga H, Mikoshiba K |title=The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9212-8 |year= 2002 |pmid= 11773082 |doi= 10.1074/jbc.M112414200 }}
*{{cite journal  | vauthors=Kuroda TS, Fukuda M, Ariga H, Mikoshiba K |title=The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9212–8 |year= 2002 |pmid= 11773082 |doi= 10.1074/jbc.M112414200 }}
*{{cite journal | author=Yi Z, Yokota H, Torii S, ''et al.'' |title=The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. |journal=Mol. Cell. Biol. |volume=22 |issue= 6 |pages= 1858-67 |year= 2002 |pmid= 11865063 |doi=  }}
*{{cite journal   |vauthors=Yi Z, Yokota H, Torii S, etal |title=The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. |journal=Mol. Cell. Biol. |volume=22 |issue= 6 |pages= 1858–67 |year= 2002 |pmid= 11865063 |doi=10.1128/MCB.22.6.1858-1867.2002  | pmc=135591 }}
*{{cite journal | author=Zhao S, Torii S, Yokota-Hashimoto H, ''et al.'' |title=Involvement of Rab27b in the regulated secretion of pituitary hormones. |journal=Endocrinology |volume=143 |issue= 5 |pages= 1817-24 |year= 2002 |pmid= 11956164 |doi=  }}
*{{cite journal   |vauthors=Zhao S, Torii S, Yokota-Hashimoto H, etal |title=Involvement of Rab27b in the regulated secretion of pituitary hormones. |journal=Endocrinology |volume=143 |issue= 5 |pages= 1817–24 |year= 2002 |pmid= 11956164 |doi=10.1210/en.143.5.1817 }}
*{{cite journal | author=Torii S, Zhao S, Yi Z, ''et al.'' |title=Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a. |journal=Mol. Cell. Biol. |volume=22 |issue= 15 |pages= 5518-26 |year= 2002 |pmid= 12101244 |doi=  }}
*{{cite journal   |vauthors=Torii S, Zhao S, Yi Z, etal |title=Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a. |journal=Mol. Cell. Biol. |volume=22 |issue= 15 |pages= 5518–26 |year= 2002 |pmid= 12101244 |doi=10.1128/MCB.22.15.5518-5526.2002  | pmc=133943 }}
*{{cite journal | author=Fukuda M, Kanno E, Saegusa C, ''et al.'' |title=Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cells. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39673-8 |year= 2002 |pmid= 12176990 |doi= 10.1074/jbc.M205349200 }}
*{{cite journal   |vauthors=Fukuda M, Kanno E, Saegusa C, etal |title=Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cells. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39673–8 |year= 2002 |pmid= 12176990 |doi= 10.1074/jbc.M205349200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Fukuda M |title=Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15390-6 |year= 2003 |pmid= 12590134 |doi= 10.1074/jbc.M213090200 }}
*{{cite journal  | author=Fukuda M |title=Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15390–6 |year= 2003 |pmid= 12590134 |doi= 10.1074/jbc.M213090200 }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal   |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Ciufo LF, Barclay JW, Burgoyne RD, Morgan A |title=Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions. |journal=Mol. Biol. Cell |volume=16 |issue= 2 |pages= 470-82 |year= 2005 |pmid= 15563604 |doi= 10.1091/mbc.E04-08-0685 }}
*{{cite journal  | vauthors=Ciufo LF, Barclay JW, Burgoyne RD, Morgan A |title=Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions. |journal=Mol. Biol. Cell |volume=16 |issue= 2 |pages= 470–82 |year= 2005 |pmid= 15563604 |doi= 10.1091/mbc.E04-08-0685 | pmc=545880 }}
*{{cite journal | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal   |vauthors=Ross MT, Grafham DV, Coffey AJ, etal |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Plaisance V, Abderrahmani A, Perret-Menoud V, ''et al.'' |title=MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells. |journal=J. Biol. Chem. |volume=281 |issue= 37 |pages= 26932-42 |year= 2006 |pmid= 16831872 |doi= 10.1074/jbc.M601225200 }}
*{{cite journal   |vauthors=Plaisance V, Abderrahmani A, Perret-Menoud V, etal |title=MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells. |journal=J. Biol. Chem. |volume=281 |issue= 37 |pages= 26932–42 |year= 2006 |pmid= 16831872 |doi= 10.1074/jbc.M601225200 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=94121}}
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Latest revision as of 07:24, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Synaptotagmin-like protein 4 is a protein that in humans is encoded by the SYTL4 gene.[1]


References

  1. ↑ "Entrez Gene: SYTL4 synaptotagmin-like 4 (granuphilin-a)".

Further reading



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