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{{Infobox_gene}}
{{PBB_Controls
'''Lysosomal-associated transmembrane protein 4B''' is a [[protein]] that in humans is encoded by the ''LAPTM4B'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LAPTM4B lysosomal associated protein transmembrane 4 beta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55353| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
LAPTM4B protein contains a [[lysosome]] localization motif and localizes on late [[endosome]]s and lysosomes.
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Lysosomal associated protein transmembrane 4 beta
| HGNCid = 13646
| Symbol = LAPTM4B
| AltSymbols =; LAPTM4beta; LC27
| OMIM = 
| ECnumber = 
| Homologene = 10182
| MGIid = 1890494
| Function =
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55353
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_060877
    | Hs_RefseqmRNA = NM_018407
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 114128
    | Mm_Ensembl = ENSMUSG00000022257
    | Mm_RefseqmRNA = NM_033521
    | Mm_RefseqProtein = NP_277056
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 34182615
    | Mm_GenLoc_end = 34228884
    | Mm_Uniprot = Q91XQ6
  }}
}}
'''Lysosomal associated protein transmembrane 4 beta''', also known as '''LAPTM4B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LAPTM4B lysosomal associated protein transmembrane 4 beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55353| accessdate = }}</ref>


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== Clinical significance ==
{{PBB_Summary
 
| section_title =  
Increased expression of LAPTM4B has been found in breast, liver, lung, ovarian, uterine, gastric cancers. Elevated LAPTM4B level contributes to [[chemotherapy]] resistance in [[breast cancer]]. It was found that overexpression of LAPTM4B causes [[anthracycline]]s ([[doxorubicin]], [[daunorubicin]], and [[epirubicin]]) resistance by retaining drug in the cytoplasm and decreasing nuclear localization of drug and drug induced DNA damage.<ref name="pmid20098429">{{cite journal |vauthors=Li Y, Zou L, Li Q, Haibe-Kains B, Tian R, Li Y, Desmedt C, Sotiriou C, Szallasi Z, Iglehart JD, Richardson AL, Wang ZC | title = Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer | journal = Nat. Med. | volume = 16 | issue = 2 | pages = 214–8 |date=February 2010 | pmid = 20098429 | pmc = 2826790 | doi = 10.1038/nm.2090  }}</ref>
| summary_text =  
 
}}
In 2011, the same group reported that LAPTM4B also promotes [[autophagy]], a cell survival mechanism mediated by lysosomes. LAPTM4B promotes autophagy and renders tumor cells resistant to metabolic and genotoxic stress and results in more rapid tumor growth.<ref name="pmid22037872">{{cite journal |vauthors=Li Y, Zhang Q, Tian R, Wang Q, Zhao JJ, Iglehart JD, Wang ZC, Richardson AL | title = Lysosomal transmembrane protein LAPTM4B promotes autophagy and tolerance to metabolic stress in cancer cells | journal = Cancer Res. | volume = 71 | issue = 24 | pages = 7481–9 |date=December 2011 | pmid = 22037872 | doi = 10.1158/0008-5472.CAN-11-0940 | pmc=3261660}}</ref>
 
Based on these findings, LAPTM4B can be utilized to be a therapeutic target to prevent chemotherapy resistance or a marker to identify the patients who will not benefit from anthracyclines.<ref name="pmid20098429"/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
| citations =
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  |vauthors=With S, Rice T, Salinas C, Auld V |title=Fire exit is a potential four transmembrane protein expressed in developing Drosophila glia. |journal=Genesis |volume=35 |issue= 3 |pages= 143–52 |year= 2003 |pmid= 12640618 |doi= 10.1002/gene.10177 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Shao GZ, Zhou RL, Zhang QY, etal |title=Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma. |journal=Oncogene |volume=22 |issue= 32 |pages= 5060–9 |year= 2003 |pmid= 12902989 |doi= 10.1038/sj.onc.1206832 }}
*{{cite journal  | author=With S, Rice T, Salinas C, Auld V |title=Fire exit is a potential four transmembrane protein expressed in developing Drosophila glia. |journal=Genesis |volume=35 |issue= 3 |pages= 143-52 |year= 2003 |pmid= 12640618 |doi= 10.1002/gene.10177 }}
*{{cite journal   |vauthors=Liu XR, Zhou RL, Zhang QY, etal |title=Structure analysis and expressions of a novel tetratransmembrane protein, lysosoma-associated protein transmembrane 4 beta associated with hepatocellular carcinoma. |journal=World J. Gastroenterol. |volume=10 |issue= 11 |pages= 1555–9 |year= 2004 |pmid= 15162524 |doi=  }}
*{{cite journal | author=Shao GZ, Zhou RL, Zhang QY, ''et al.'' |title=Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma. |journal=Oncogene |volume=22 |issue= 32 |pages= 5060-9 |year= 2003 |pmid= 12902989 |doi= 10.1038/sj.onc.1206832 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Liu XR, Zhou RL, Zhang QY, ''et al.'' |title=Structure analysis and expressions of a novel tetratransmembrane protein, lysosoma-associated protein transmembrane 4 beta associated with hepatocellular carcinoma. |journal=World J. Gastroenterol. |volume=10 |issue= 11 |pages= 1555-9 |year= 2004 |pmid= 15162524 |doi=  }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Kasper G, Vogel A, Klaman I, etal |title=The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression. |journal=Cancer Lett. |volume=224 |issue= 1 |pages= 93–103 |year= 2005 |pmid= 15911104 |doi= 10.1016/j.canlet.2004.10.004 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Kasper G, Vogel A, Klaman I, ''et al.'' |title=The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression. |journal=Cancer Lett. |volume=224 |issue= 1 |pages= 93-103 |year= 2005 |pmid= 15911104 |doi= 10.1016/j.canlet.2004.10.004 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal   |vauthors=Maeda K, Horikoshi T, Nakashima E, etal |title=MATN and LAPTM are parts of larger transcription units produced by intergenic splicing: intergenic splicing may be a common phenomenon. |journal=DNA Res. |volume=12 |issue= 5 |pages= 365–72 |year= 2007 |pmid= 16769693 |doi= 10.1093/dnares/dsi017 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal  |vauthors=Liu Y, Zhang QY, Qian N, Zhou RL |title=Relationship between LAPTM4B gene polymorphism and susceptibility of gastric cancer. |journal=Ann. Oncol. |volume=18 |issue= 2 |pages= 311–6 |year= 2007 |pmid= 17074969 |doi= 10.1093/annonc/mdl394 }}
*{{cite journal | author=Maeda K, Horikoshi T, Nakashima E, ''et al.'' |title=MATN and LAPTM are parts of larger transcription units produced by intergenic splicing: intergenic splicing may be a common phenomenon. |journal=DNA Res. |volume=12 |issue= 5 |pages= 365-72 |year= 2007 |pmid= 16769693 |doi= 10.1093/dnares/dsi017 }}
*{{cite journal  | author=Liu Y, Zhang QY, Qian N, Zhou RL |title=Relationship between LAPTM4B gene polymorphism and susceptibility of gastric cancer. |journal=Ann. Oncol. |volume=18 |issue= 2 |pages= 311-6 |year= 2007 |pmid= 17074969 |doi= 10.1093/annonc/mdl394 }}
}}
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Latest revision as of 17:33, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Lysosomal-associated transmembrane protein 4B is a protein that in humans is encoded by the LAPTM4B gene.[1]

LAPTM4B protein contains a lysosome localization motif and localizes on late endosomes and lysosomes.

Clinical significance

Increased expression of LAPTM4B has been found in breast, liver, lung, ovarian, uterine, gastric cancers. Elevated LAPTM4B level contributes to chemotherapy resistance in breast cancer. It was found that overexpression of LAPTM4B causes anthracyclines (doxorubicin, daunorubicin, and epirubicin) resistance by retaining drug in the cytoplasm and decreasing nuclear localization of drug and drug induced DNA damage.[2]

In 2011, the same group reported that LAPTM4B also promotes autophagy, a cell survival mechanism mediated by lysosomes. LAPTM4B promotes autophagy and renders tumor cells resistant to metabolic and genotoxic stress and results in more rapid tumor growth.[3]

Based on these findings, LAPTM4B can be utilized to be a therapeutic target to prevent chemotherapy resistance or a marker to identify the patients who will not benefit from anthracyclines.[2]

References

  1. ↑ "Entrez Gene: LAPTM4B lysosomal associated protein transmembrane 4 beta".
  2. ↑ 2.0 2.1 Li Y, Zou L, Li Q, Haibe-Kains B, Tian R, Li Y, Desmedt C, Sotiriou C, Szallasi Z, Iglehart JD, Richardson AL, Wang ZC (February 2010). "Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer". Nat. Med. 16 (2): 214–8. doi:10.1038/nm.2090. PMC 2826790. PMID 20098429.
  3. ↑ Li Y, Zhang Q, Tian R, Wang Q, Zhao JJ, Iglehart JD, Wang ZC, Richardson AL (December 2011). "Lysosomal transmembrane protein LAPTM4B promotes autophagy and tolerance to metabolic stress in cancer cells". Cancer Res. 71 (24): 7481–9. doi:10.1158/0008-5472.CAN-11-0940. PMC 3261660. PMID 22037872.

Further reading


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