OAS2: Difference between revisions

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{{Infobox_gene}}
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'''2'-5'-oligoadenylate synthetase 2''' is an [[enzyme]] that in humans is encoded by the ''OAS2'' [[gene]].<ref name="pmid9790745">{{cite journal |vauthors=Hovnanian A, Rebouillat D, Mattei MG, Levy ER, Marie I, Monaco AP, Hovanessian AG | title = The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms | journal = Genomics | volume = 52 | issue = 3 | pages = 267–277 |date=Dec 1998 | pmid = 9790745 | pmc =  | doi = 10.1006/geno.1998.5443 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4939| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = 2'-5'-oligoadenylate synthetase 2, 69/71kDa
| HGNCid = 8087
| Symbol = OAS2
| AltSymbols =; MGC78578
| OMIM = 603350
| ECnumber = 
| Homologene = 49478
| MGIid = 2180852
| GeneAtlas_image1 = PBB_GE_OAS2_204972_at_tn.png
| Function = {{GNF_GO|id=GO:0001730 |text = 2'-5'-oligoadenylate synthetase activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006139 |text = nucleobase, nucleoside, nucleotide and nucleic acid metabolic process}} {{GNF_GO|id=GO:0006401 |text = RNA catabolic process}} {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4939
    | Hs_Ensembl = ENSG00000111335
    | Hs_RefseqProtein = NP_001027903
    | Hs_RefseqmRNA = NM_001032731
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 111900657
    | Hs_GenLoc_end = 111933911
    | Hs_Uniprot = P29728
    | Mm_EntrezGene = 246728
    | Mm_Ensembl = ENSMUSG00000032690
    | Mm_RefseqmRNA = NM_145227
    | Mm_RefseqProtein = NP_660262
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 120990951
    | Mm_GenLoc_end = 121010470
    | Mm_Uniprot = 
  }}
}}
'''2'-5'-oligoadenylate synthetase 2, 69/71kDa''', also known as '''OAS2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4939| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4939| accessdate = }}</ref>
| summary_text = This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent [[RNase L]], which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Justesen J, Hartmann R, Kjeldgaard NO |title=Gene structure and function of the 2'-5'-oligoadenylate synthetase family. |journal=Cell. Mol. Life Sci. |volume=57 |issue= 11 |pages= 1593-612 |year= 2000 |pmid= 11092454 |doi=  }}
*{{cite journal  |vauthors=Justesen J, Hartmann R, Kjeldgaard NO |title=Gene structure and function of the 2'-5'-oligoadenylate synthetase family |journal=Cell. Mol. Life Sci. |volume=57 |issue= 11 |pages= 1593–1612 |year= 2000 |pmid= 11092454 |doi=10.1007/PL00000644 }}
*{{cite journal  | author=Marié I, Hovanessian AG |title=The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains. |journal=J. Biol. Chem. |volume=267 |issue= 14 |pages= 9933-9 |year= 1992 |pmid= 1577824 |doi=  }}
*{{cite journal  |vauthors=Marié I, Hovanessian AG |title=The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains |journal=J. Biol. Chem. |volume=267 |issue= 14 |pages= 9933–9 |year= 1992 |pmid= 1577824 |doi=  }}
*{{cite journal  | author=Silverman RH, Sengupta DN |title=Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes. |journal=J. Exp. Pathol. |volume=5 |issue= 2 |pages= 69-77 |year= 1991 |pmid= 1708818 |doi=  }}
*{{cite journal  |vauthors=Silverman RH, Sengupta DN |title=Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes |journal=J. Exp. Pathol. |volume=5 |issue= 2 |pages= 69–77 |year= 1991 |pmid= 1708818 |doi=  }}
*{{cite journal  | author=Marié I, Svab J, Robert N, ''et al.'' |title=Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon. |journal=J. Biol. Chem. |volume=265 |issue= 30 |pages= 18601-7 |year= 1990 |pmid= 2211721 |doi=  }}
*{{cite journal  | author=Marié I |title=Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon |journal=J. Biol. Chem. |volume=265 |issue= 30 |pages= 18601–7 |year= 1990 |pmid= 2211721 |doi= |name-list-format=vanc| author2=Svab J  | author3=Robert N  | display-authors=3  | last4=Galabru  | first4=J  | last5=Hovanessian  | first5=AG }}
*{{cite journal  | author=Hovanessian AG, Laurent AG, Chebath J, ''et al.'' |title=Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies. |journal=EMBO J. |volume=6 |issue= 5 |pages= 1273-80 |year= 1987 |pmid= 2440675 |doi=  }}
*{{cite journal  | author=Hovanessian AG |title=Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies |journal=EMBO J. |volume=6 |issue= 5 |pages= 1273–80 |year= 1987 |pmid= 2440675 |doi= | pmc=553929  |name-list-format=vanc| author2=Laurent AG  | author3=Chebath J  | display-authors=3  | last4=Galabru  | first4=J  | last5=Robert  | first5=N  | last6=Svab  | first6=J }}
*{{cite journal  | author=Marié I, Galabru J, Svab J, Hovanessian AG |title=Preparation and characterization of polyclonal antibodies specific for the 69 and 100 k-dalton forms of human 2-5A synthetase. |journal=Biochem. Biophys. Res. Commun. |volume=160 |issue= 2 |pages= 580-7 |year= 1989 |pmid= 2470369 |doi=  }}
*{{cite journal  |vauthors=Marié I, Galabru J, Svab J, Hovanessian AG |title=Preparation and characterization of polyclonal antibodies specific for the 69 and 100 k-dalton forms of human 2-5A synthetase |journal=Biochem. Biophys. Res. Commun. |volume=160 |issue= 2 |pages= 580–587 |year= 1989 |pmid= 2470369 |doi=10.1016/0006-291X(89)92472-8 }}
*{{cite journal  | author=Hovanessian AG, Svab J, Marié I, ''et al.'' |title=Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells. |journal=J. Biol. Chem. |volume=263 |issue= 10 |pages= 4945-9 |year= 1988 |pmid= 3350819 |doi=  }}
*{{cite journal  | author=Hovanessian AG |title=Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells |journal=J. Biol. Chem. |volume=263 |issue= 10 |pages= 4945–9 |year= 1988 |pmid= 3350819 |doi= |name-list-format=vanc| author2=Svab J  | author3=Marié I  | display-authors=3  | last4=Robert  | first4=N  | last5=Chamaret  | first5=S  | last6=Laurent  | first6=AG }}
*{{cite journal  | author=Solinas A, Cossu P, Poddighe P, ''et al.'' |title=Changes of serum 2',5'-oligoadenylate synthetase activity during interferon treatment of chronic hepatitis C. |journal=Liver |volume=13 |issue= 5 |pages= 253-8 |year= 1994 |pmid= 8259037 |doi=  }}
*{{cite journal  | author=Solinas A |title=Changes of serum 2',5'-oligoadenylate synthetase activity during interferon treatment of chronic hepatitis C |journal=Liver |volume=13 |issue= 5 |pages= 253–8 |year= 1994 |pmid= 8259037 |doi= |name-list-format=vanc| author2=Cossu P  | author3=Poddighe P  | display-authors=3  | last4=Tocco  | first4=A  | last5=Deplano  | first5=A  | last6=Garrucciu  | first6=G  | last7=Diana  | first7=MS }}
*{{cite journal  | author=Besse S, Rebouillat D, Marie I, ''et al.'' |title=Ultrastructural localization of interferon-inducible double-stranded RNA-activated enzymes in human cells. |journal=Exp. Cell Res. |volume=239 |issue= 2 |pages= 379-92 |year= 1998 |pmid= 9521856 |doi=  }}
*{{cite journal  | author=Besse S |title=Ultrastructural localization of interferon-inducible double-stranded RNA-activated enzymes in human cells |journal=Exp. Cell Res. |volume=239 |issue= 2 |pages= 379–392 |year= 1998 |pmid= 9521856 |doi=10.1006/excr.1997.3908 |name-list-format=vanc| author2=Rebouillat D  | author3=Marie I  | display-authors=3 | last4=Puvion-Dutilleul  | first4=F  | last5=Hovanessian  | first5=AG  }}
*{{cite journal  | author=Hovnanian A, Rebouillat D, Mattei MG, ''et al.'' |title=The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms. |journal=Genomics |volume=52 |issue= 3 |pages= 267-77 |year= 1998 |pmid= 9790745 |doi= 10.1006/geno.1998.5443 }}
*{{cite journal  | author=Sarkar SN |title=The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases |journal=J. Biol. Chem. |volume=274 |issue= 36 |pages= 25535–25542 |year= 1999 |pmid= 10464285 |doi=10.1074/jbc.274.36.25535  |name-list-format=vanc| author2=Ghosh A  | author3=Wang HW  | display-authors=3  | last4=Sung  | first4=SS  | last5=Sen  | first5=GC }}
*{{cite journal  | author=Sarkar SN, Ghosh A, Wang HW, ''et al.'' |title=The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases. |journal=J. Biol. Chem. |volume=274 |issue= 36 |pages= 25535-42 |year= 1999 |pmid= 10464285 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Scherer SE |title=The finished DNA sequence of human chromosome 12 |journal=Nature |volume=440 |issue= 7082 |pages= 346–351 |year= 2006 |pmid= 16541075 |doi= 10.1038/nature04569 |name-list-format=vanc| author2=Muzny DM  | author3=Buhay CJ  | display-authors=3  | last4=Chen  | first4=Rui  | last5=Cree  | first5=Andrew  | last6=Ding  | first6=Yan  | last7=Dugan-Rocha  | first7=Shannon  | last8=Gill  | first8=Rachel  | last9=Gunaratne  | first9=Preethi }}
*{{cite journal  | author=Scherer SE, Muzny DM, Buhay CJ, ''et al.'' |title=The finished DNA sequence of human chromosome 12. |journal=Nature |volume=440 |issue= 7082 |pages= 346-51 |year= 2006 |pmid= 16541075 |doi= 10.1038/nature04569 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 00:19, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

2'-5'-oligoadenylate synthetase 2 is an enzyme that in humans is encoded by the OAS2 gene.[1][2]

This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.[2]

References

  1. ↑ Hovnanian A, Rebouillat D, Mattei MG, Levy ER, Marie I, Monaco AP, Hovanessian AG (Dec 1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms". Genomics. 52 (3): 267–277. doi:10.1006/geno.1998.5443. PMID 9790745.
  2. ↑ 2.0 2.1 "Entrez Gene: OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa".

Further reading



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