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{{Infobox_gene}}
{{PBB_Controls
'''Protein deltex-1''' is a [[protein]] that in humans is encoded by the ''DTX1'' [[gene]].<ref name="pmid9590294">{{cite journal | vauthors = Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S | title = Human deltex is a conserved regulator of Notch signalling | journal = Nature Genetics | volume = 19 | issue = 1 | pages = 74–8 | date = May 1998 | pmid = 9590294 | pmc =  | doi = 10.1038/ng0598-74 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DTX1 deltex homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1840| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Deltex homolog 1 (Drosophila)
| HGNCid = 3060
| Symbol = DTX1
| AltSymbols =; hDx-1
| OMIM = 602582
| ECnumber = 
| Homologene = 74522
| MGIid = 1352744
| GeneAtlas_image1 = PBB_GE_DTX1_gnf1h00055_at_tn.png
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005112 |text = Notch binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0008593 |text = regulation of Notch signaling pathway}} {{GNF_GO|id=GO:0010001 |text = glial cell differentiation}} {{GNF_GO|id=GO:0045665 |text = negative regulation of neuron differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1840
    | Hs_Ensembl = ENSG00000135144
    | Hs_RefseqProtein = NP_004407
    | Hs_RefseqmRNA = NM_004416
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 111980045
    | Hs_GenLoc_end = 112020216
    | Hs_Uniprot = Q86Y01
    | Mm_EntrezGene = 14357
    | Mm_Ensembl = ENSMUSG00000029603
    | Mm_RefseqmRNA = NM_008052
    | Mm_RefseqProtein = NP_032078
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 120940820
    | Mm_GenLoc_end = 120972241
    | Mm_Uniprot = Q5DTK6
  }}
}}
'''Deltex homolog 1 (Drosophila)''', also known as '''DTX1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DTX1 deltex homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1840| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Studies in Drosophila have identified this gene as encoding a positive regulator of the [[notch signaling pathway]]. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.<ref name="entrez">{{cite web | title = Entrez Gene: DTX1 deltex homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1840| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
DTX1 has been shown to [[Protein-protein interaction|interact]] with [[EP300]].<ref name=pmid11564735>{{cite journal | vauthors = Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M | title = Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor | journal = The Journal of Biological Chemistry | volume = 276 | issue = 48 | pages = 45031–40 | date = Nov 2001 | pmid = 11564735 | doi = 10.1074/jbc.M105245200 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Saito T, Chiba S, Ichikawa M, Kunisato A, Asai T, Shimizu K, Yamaguchi T, Yamamoto G, Seo S, Kumano K, Nakagami-Yamaguchi E, Hamada Y, Aizawa S, Hirai H | title = Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development | journal = Immunity | volume = 18 | issue = 5 | pages = 675–85 | date = May 2003 | pmid = 12753744 | doi = 10.1016/S1074-7613(03)00111-0 }}
| citations =
* {{cite journal | vauthors = Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA | title = The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity | journal = The Journal of Biological Chemistry | volume = 278 | issue = 24 | pages = 21930–7 | date = Jun 2003 | pmid = 12670957 | doi = 10.1074/jbc.M301157200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Gupta-Rossi N, Storck S, Griebel PJ, Reynaud CA, Weill JC, Dahan A | title = Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells | journal = Molecular Immunology | volume = 39 | issue = 13 | pages = 791–9 | date = Mar 2003 | pmid = 12617994 | doi = 10.1016/S0161-5890(03)00002-6 }}
*{{cite journal  | author=Saito T, Chiba S, Ichikawa M, ''et al.'' |title=Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. |journal=Immunity |volume=18 |issue= 5 |pages= 675-85 |year= 2003 |pmid= 12753744 |doi= }}
* {{cite journal | vauthors = Izon DJ, Aster JC, He Y, Weng A, Karnell FG, Patriub V, Xu L, Bakkour S, Rodriguez C, Allman D, Pear WS | title = Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1 | journal = Immunity | volume = 16 | issue = 2 | pages = 231–43 | date = Feb 2002 | pmid = 11869684 | doi = 10.1016/S1074-7613(02)00271-6 }}
*{{cite journal | author=Takeyama K, Aguiar RC, Gu L, ''et al.'' |title=The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 21930-7 |year= 2003 |pmid= 12670957 |doi= 10.1074/jbc.M301157200 }}
* {{cite journal | vauthors = Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M | title = Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor | journal = The Journal of Biological Chemistry | volume = 276 | issue = 48 | pages = 45031–40 | date = Nov 2001 | pmid = 11564735 | doi = 10.1074/jbc.M105245200 }}
*{{cite journal | author=Gupta-Rossi N, Storck S, Griebel PJ, ''et al.'' |title=Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells. |journal=Mol. Immunol. |volume=39 |issue= 13 |pages= 791-9 |year= 2003 |pmid= 12617994 |doi= }}
* {{cite journal | vauthors = Kishi N, Tang Z, Maeda Y, Hirai A, Mo R, Ito M, Suzuki S, Nakao K, Kinoshita T, Kadesch T, Hui C, Artavanis-Tsakonas S, Okano H, Matsuno K | title = Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis | journal = International Journal of Developmental Neuroscience | volume = 19 | issue = 1 | pages = 21–35 | date = Feb 2001 | pmid = 11226752 | doi = 10.1016/S0736-5748(00)00071-X }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Lee L, Dowhanick-Morrissette J, Katz A, Jukofsky L, Krantz ID | title = Chromosomal localization, genomic characterization, and mapping to the Noonan syndrome critical region of the human Deltex (DTX1) gene | journal = Human Genetics | volume = 107 | issue = 6 | pages = 577–81 | date = Dec 2000 | pmid = 11153911 | doi = 10.1007/s004390000431 }}
*{{cite journal | author=Izon DJ, Aster JC, He Y, ''et al.'' |title=Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. |journal=Immunity |volume=16 |issue= 2 |pages= 231-43 |year= 2002 |pmid= 11869684 |doi= }}
* {{cite journal | vauthors = Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S | title = Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane | journal = Cell | volume = 90 | issue = 2 | pages = 281–91 | date = Jul 1997 | pmid = 9244302 | doi = 10.1016/S0092-8674(00)80336-0 }}
*{{cite journal | author=Yamamoto N, Yamamoto S, Inagaki F, ''et al.'' |title=Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor. |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 45031-40 |year= 2002 |pmid= 11564735 |doi= 10.1074/jbc.M105245200 }}
* {{cite journal | vauthors = Matsuno K, Diederich RJ, Go MJ, Blaumueller CM, Artavanis-Tsakonas S | title = Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats | journal = Development | volume = 121 | issue = 8 | pages = 2633–44 | date = Aug 1995 | pmid = 7671825 | doi =  }}
*{{cite journal | author=Kishi N, Tang Z, Maeda Y, ''et al.'' |title=Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. |journal=Int. J. Dev. Neurosci. |volume=19 |issue= 1 |pages= 21-35 |year= 2001 |pmid= 11226752 |doi= }}
*{{cite journal | author=Lee L, Dowhanick-Morrissette J, Katz A, ''et al.'' |title=Chromosomal localization, genomic characterization, and mapping to the Noonan syndrome critical region of the human Deltex (DTX1) gene. |journal=Hum. Genet. |volume=107 |issue= 6 |pages= 577-81 |year= 2001 |pmid= 11153911 |doi=  }}
*{{cite journal  | author=Matsuno K, Eastman D, Mitsiades T, ''et al.'' |title=Human deltex is a conserved regulator of Notch signalling. |journal=Nat. Genet. |volume=19 |issue= 1 |pages= 74-8 |year= 1998 |pmid= 9590294 |doi= 10.1038/ng0598-74 }}
*{{cite journal | author=Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S |title=Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. |journal=Cell |volume=90 |issue= 2 |pages= 281-91 |year= 1997 |pmid= 9244302 |doi= }}
*{{cite journal | author=Matsuno K, Diederich RJ, Go MJ, ''et al.'' |title=Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. |journal=Development |volume=121 |issue= 8 |pages= 2633-44 |year= 1995 |pmid= 7671825 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
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Latest revision as of 03:11, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein deltex-1 is a protein that in humans is encoded by the DTX1 gene.[1][2]

Function

Studies in Drosophila have identified this gene as encoding a positive regulator of the notch signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.[2]

Interactions

DTX1 has been shown to interact with EP300.[3]

References

  1. ↑ Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S (May 1998). "Human deltex is a conserved regulator of Notch signalling". Nature Genetics. 19 (1): 74–8. doi:10.1038/ng0598-74. PMID 9590294.
  2. ↑ 2.0 2.1 "Entrez Gene: DTX1 deltex homolog 1 (Drosophila)".
  3. ↑ Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M (Nov 2001). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". The Journal of Biological Chemistry. 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735.

Further reading

  • Saito T, Chiba S, Ichikawa M, Kunisato A, Asai T, Shimizu K, Yamaguchi T, Yamamoto G, Seo S, Kumano K, Nakagami-Yamaguchi E, Hamada Y, Aizawa S, Hirai H (May 2003). "Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development". Immunity. 18 (5): 675–85. doi:10.1016/S1074-7613(03)00111-0. PMID 12753744.
  • Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (Jun 2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". The Journal of Biological Chemistry. 278 (24): 21930–7. doi:10.1074/jbc.M301157200. PMID 12670957.
  • Gupta-Rossi N, Storck S, Griebel PJ, Reynaud CA, Weill JC, Dahan A (Mar 2003). "Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells". Molecular Immunology. 39 (13): 791–9. doi:10.1016/S0161-5890(03)00002-6. PMID 12617994.
  • Izon DJ, Aster JC, He Y, Weng A, Karnell FG, Patriub V, Xu L, Bakkour S, Rodriguez C, Allman D, Pear WS (Feb 2002). "Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1". Immunity. 16 (2): 231–43. doi:10.1016/S1074-7613(02)00271-6. PMID 11869684.
  • Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M (Nov 2001). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". The Journal of Biological Chemistry. 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735.
  • Kishi N, Tang Z, Maeda Y, Hirai A, Mo R, Ito M, Suzuki S, Nakao K, Kinoshita T, Kadesch T, Hui C, Artavanis-Tsakonas S, Okano H, Matsuno K (Feb 2001). "Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis". International Journal of Developmental Neuroscience. 19 (1): 21–35. doi:10.1016/S0736-5748(00)00071-X. PMID 11226752.
  • Lee L, Dowhanick-Morrissette J, Katz A, Jukofsky L, Krantz ID (Dec 2000). "Chromosomal localization, genomic characterization, and mapping to the Noonan syndrome critical region of the human Deltex (DTX1) gene". Human Genetics. 107 (6): 577–81. doi:10.1007/s004390000431. PMID 11153911.
  • Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (Jul 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell. 90 (2): 281–91. doi:10.1016/S0092-8674(00)80336-0. PMID 9244302.
  • Matsuno K, Diederich RJ, Go MJ, Blaumueller CM, Artavanis-Tsakonas S (Aug 1995). "Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats". Development. 121 (8): 2633–44. PMID 7671825.


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