SLC22A11: Difference between revisions

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{{Infobox_gene}}
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'''Solute carrier family 22 member 11''' is a [[protein]] that in humans is encoded by the ''SLC22A11'' [[gene]].<ref name="pmid10660625">{{cite journal | vauthors = Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H | title = Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta | journal = J Biol Chem | volume = 275 | issue = 6 | pages = 4507–12 |date=Mar 2000 | pmid = 10660625 | pmc =  | doi =10.1074/jbc.275.6.4507 }}</ref><ref name="pmid15576633">{{cite journal | vauthors = Zhou F, Xu W, Hong M, Pan Z, Sinko PJ, Ma J, You G | title = The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4 | journal = Mol Pharmacol | volume = 67 | issue = 3 | pages = 868–76 |date=Feb 2005 | pmid = 15576633 | pmc = | doi = 10.1124/mol.104.007583 }}</ref><ref name="pmid17229912">{{cite journal | vauthors = Hagos Y, Stein D, Ugele B, Burckhardt G, Bahn A | title = Human renal organic anion transporter 4 operates as an asymmetric urate transporter | journal = J Am Soc Nephrol | volume = 18 | issue = 2 | pages = 430–9 |date=Jan 2007 | pmid = 17229912 | pmc =  | doi = 10.1681/ASN.2006040415 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC22A11 solute carrier family 22 (organic anion/cation transporter), member 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55867| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Solute carrier family 22 (organic anion/cation transporter), member 11
| HGNCid = 18120
| Symbol = SLC22A11
| AltSymbols =; MGC34282; OAT4; hOAT4
| OMIM = 607097
| ECnumber =
| Homologene = 81863
| MGIid =
  | GeneAtlas_image1 = PBB_GE_SLC22A11_220100_at_tn.png
  | Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0015347 |text = sodium-independent organic anion transmembrane transporter activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55867
    | Hs_Ensembl = ENSG00000168065
    | Hs_RefseqProtein = NP_060954
    | Hs_RefseqmRNA = NM_018484
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 64079674
    | Hs_GenLoc_end = 64095575
    | Hs_Uniprot = Q9NSA0
    | Mm_EntrezGene =   
    | Mm_Ensembl =
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Solute carrier family 22 (organic anion/cation transporter), member 11''', also known as '''SLC22A11''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC22A11 solute carrier family 22 (organic anion/cation transporter), member 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55867| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus.<ref name="entrez">{{cite web | title = Entrez Gene: SLC22A11 solute carrier family 22 (organic anion/cation transporter), member 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55867| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Cha SH, Sekine T, Kusuhara H, ''et al.'' |title=Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. |journal=J. Biol. Chem. |volume=275 |issue= 6 |pages= 4507-12 |year= 2000 |pmid= 10660625 |doi= }}
*{{cite journal  | vauthors=Sun W, Wu RR, van Poelje PD, Erion MD |title=Isolation of a family of organic anion transporters from human liver and kidney |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 2 |pages= 417–22 |year= 2001 |pmid= 11327718 |doi= 10.1006/bbrc.2001.4774 }}
*{{cite journal  | author=Sun W, Wu RR, van Poelje PD, Erion MD |title=Isolation of a family of organic anion transporters from human liver and kidney. |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 2 |pages= 417-22 |year= 2001 |pmid= 11327718 |doi= 10.1006/bbrc.2001.4774 }}
*{{cite journal   |vauthors=Babu E, Takeda M, Narikawa S, etal |title=Human organic anion transporters mediate the transport of tetracycline |journal=Jpn. J. Pharmacol. |volume=88 |issue= 1 |pages= 69–76 |year= 2002 |pmid= 11855680 |doi=10.1254/jjp.88.69 }}
*{{cite journal | author=Babu E, Takeda M, Narikawa S, ''et al.'' |title=Human organic anion transporters mediate the transport of tetracycline. |journal=Jpn. J. Pharmacol. |volume=88 |issue= 1 |pages= 69-76 |year= 2002 |pmid= 11855680 |doi=  }}
*{{cite journal   |vauthors=Kimura H, Takeda M, Narikawa S, etal |title=Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins |journal=J. Pharmacol. Exp. Ther. |volume=301 |issue= 1 |pages= 293–8 |year= 2002 |pmid= 11907186 |doi=10.1124/jpet.301.1.293 }}
*{{cite journal | author=Kimura H, Takeda M, Narikawa S, ''et al.'' |title=Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. |journal=J. Pharmacol. Exp. Ther. |volume=301 |issue= 1 |pages= 293-8 |year= 2002 |pmid= 11907186 |doi=  }}
*{{cite journal  | vauthors=Takeda M, Babu E, Narikawa S, Endou H |title=Interaction of human organic anion transporters with various cephalosporin antibiotics |journal=Eur. J. Pharmacol. |volume=438 |issue= 3 |pages= 137–42 |year= 2002 |pmid= 11909604 |doi=10.1016/S0014-2999(02)01306-7 }}
*{{cite journal  | author=Takeda M, Babu E, Narikawa S, Endou H |title=Interaction of human organic anion transporters with various cephalosporin antibiotics. |journal=Eur. J. Pharmacol. |volume=438 |issue= 3 |pages= 137-42 |year= 2002 |pmid= 11909604 |doi=  }}
*{{cite journal   |vauthors=Enomoto A, Takeda M, Shimoda M, etal |title=Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors |journal=J. Pharmacol. Exp. Ther. |volume=301 |issue= 3 |pages= 797–802 |year= 2002 |pmid= 12023506 |doi=10.1124/jpet.301.3.797 }}
*{{cite journal | author=Enomoto A, Takeda M, Shimoda M, ''et al.'' |title=Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. |journal=J. Pharmacol. Exp. Ther. |volume=301 |issue= 3 |pages= 797-802 |year= 2002 |pmid= 12023506 |doi=  }}
*{{cite journal   |vauthors=Enomoto A, Kimura H, Chairoungdua A, etal |title=Molecular identification of a renal urate anion exchanger that regulates blood urate levels |journal=Nature |volume=417 |issue= 6887 |pages= 447–52 |year= 2002 |pmid= 12024214 |doi= 10.1038/nature742 }}
*{{cite journal | author=Enomoto A, Kimura H, Chairoungdua A, ''et al.'' |title=Molecular identification of a renal urate anion exchanger that regulates blood urate levels. |journal=Nature |volume=417 |issue= 6887 |pages= 447-52 |year= 2002 |pmid= 12024214 |doi= 10.1038/nature742 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Zhou F, Tanaka K, Pan Z, etal |title=The role of glycine residues in the function of human organic anion transporter 4 |journal=Mol. Pharmacol. |volume=65 |issue= 5 |pages= 1141–7 |year= 2004 |pmid= 15102942 |doi= 10.1124/mol.65.5.1141 }}
*{{cite journal | author=Zhou F, Tanaka K, Pan Z, ''et al.'' |title=The role of glycine residues in the function of human organic anion transporter 4. |journal=Mol. Pharmacol. |volume=65 |issue= 5 |pages= 1141-7 |year= 2004 |pmid= 15102942 |doi= 10.1124/mol.65.5.1141 }}
*{{cite journal  | vauthors=Zhou F, Pan Z, Ma J, You G |title=Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4) |journal=Biochem. J. |volume=384 |issue= Pt 1 |pages= 87–92 |year= 2005 |pmid= 15291761 |doi= 10.1042/BJ20040751 | pmc=1134091 }}
*{{cite journal  | author=Zhou F, Pan Z, Ma J, You G |title=Mutational analysis of histidine residues in human organic anion transporter 4 (hOAT4). |journal=Biochem. J. |volume=384 |issue= Pt 1 |pages= 87-92 |year= 2005 |pmid= 15291761 |doi= 10.1042/BJ20040751 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Taylor TD, Noguchi H, Totoki Y, etal |title=Human chromosome 11 DNA sequence and analysis including novel gene identification |journal=Nature |volume=440 |issue= 7083 |pages= 497–500 |year= 2006 |pmid= 16554811 |doi= 10.1038/nature04632 }}
*{{cite journal | author=Zhou F, Xu W, Hong M, ''et al.'' |title=The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. |journal=Mol. Pharmacol. |volume=67 |issue= 3 |pages= 868-76 |year= 2005 |pmid= 15576633 |doi= 10.1124/mol.104.007583 }}
*{{cite journal | author=Taylor TD, Noguchi H, Totoki Y, ''et al.'' |title=Human chromosome 11 DNA sequence and analysis including novel gene identification. |journal=Nature |volume=440 |issue= 7083 |pages= 497-500 |year= 2006 |pmid= 16554811 |doi= 10.1038/nature04632 }}
*{{cite journal  | author=Hagos Y, Stein D, Ugele B, ''et al.'' |title=Human renal organic anion transporter 4 operates as an asymmetric urate transporter. |journal=J. Am. Soc. Nephrol. |volume=18 |issue= 2 |pages= 430-9 |year= 2007 |pmid= 17229912 |doi= 10.1681/ASN.2006040415 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}
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[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
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{{membrane-protein-stub}}

Latest revision as of 06:28, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.[1][2][3][4]

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus.[4]

See also

References

  1. ↑ Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H (Mar 2000). "Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta". J Biol Chem. 275 (6): 4507–12. doi:10.1074/jbc.275.6.4507. PMID 10660625.
  2. ↑ Zhou F, Xu W, Hong M, Pan Z, Sinko PJ, Ma J, You G (Feb 2005). "The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4". Mol Pharmacol. 67 (3): 868–76. doi:10.1124/mol.104.007583. PMID 15576633.
  3. ↑ Hagos Y, Stein D, Ugele B, Burckhardt G, Bahn A (Jan 2007). "Human renal organic anion transporter 4 operates as an asymmetric urate transporter". J Am Soc Nephrol. 18 (2): 430–9. doi:10.1681/ASN.2006040415. PMID 17229912.
  4. ↑ 4.0 4.1 "Entrez Gene: SLC22A11 solute carrier family 22 (organic anion/cation transporter), member 11".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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