THRSP: Difference between revisions

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{{Infobox_gene}}
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'''Thyroid hormone-inducible hepatic protein''' is a [[protein]] that in humans is encoded by the ''THRSP'' [[gene]].<ref name="pmid9003802">{{cite journal |vauthors=Grillasca JP, Gastaldi M, Khiri H, Dace A, Peyrol N, Reynier P, Torresani J, Planells R | title = Cloning and initial characterization of human and mouse Spot 14 genes | journal = FEBS Lett | volume = 401 | issue = 1 | pages = 38–42 |date=Feb 1997 | pmid = 9003802 | pmc =  | doi =10.1016/S0014-5793(96)01433-0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: THRSP thyroid hormone responsive (SPOT14 homolog, rat)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7069| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Thyroid hormone responsive (SPOT14 homolog, rat)
| HGNCid = 11800
| Symbol = THRSP
| AltSymbols =; S14; MGC21659; SPOT14
| OMIM = 601926
| ECnumber = 
| Homologene = 2441
| MGIid = 109126
| GeneAtlas_image1 = PBB_GE_THRSP_gnf1h00039_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7069
    | Hs_Ensembl = ENSG00000151365
    | Hs_RefseqProtein = NP_003242
    | Hs_RefseqmRNA = NM_003251
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 77452555
    | Hs_GenLoc_end = 77457044
    | Hs_Uniprot = Q92748
    | Mm_EntrezGene = 21835
    | Mm_Ensembl = ENSMUSG00000035686
    | Mm_RefseqmRNA = NM_009381
    | Mm_RefseqProtein = NP_033407
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 97288136
    | Mm_GenLoc_end = 97292702
    | Mm_Uniprot = Q543J4
  }}
}}
'''Thyroid hormone responsive (SPOT14 homolog, rat)''', also known as '''THRSP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: THRSP thyroid hormone responsive (SPOT14 homolog, rat)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7069| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism.<ref name="entrez">{{cite web | title = Entrez Gene: THRSP thyroid hormone responsive (SPOT14 homolog, rat)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7069| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Cunningham BA, Moncur JT, Huntington JT, Kinlaw WB |title="Spot 14" protein: a metabolic integrator in normal and neoplastic cells. |journal=Thyroid |volume=8 |issue= 9 |pages= 815-25 |year= 1998 |pmid= 9777755 |doi= }}
*{{cite journal  |vauthors=Cunningham BA, Moncur JT, Huntington JT, Kinlaw WB |title="Spot 14" protein: a metabolic integrator in normal and neoplastic cells. |journal=Thyroid |volume=8 |issue= 9 |pages= 815–25 |year= 1998 |pmid= 9777755 |doi=10.1089/thy.1998.8.815 }}
*{{cite journal  | author=Grillasca JP, Gastaldi M, Khiri H, ''et al.'' |title=Cloning and initial characterization of human and mouse Spot 14 genes. |journal=FEBS Lett. |volume=401 |issue= 1 |pages= 38-42 |year= 1997 |pmid= 9003802 |doi= }}
*{{cite journal  |vauthors=Ota Y, Mariash A, Wagner JL, Mariash CN |title=Cloning, expression and regulation of the human S14 gene. |journal=Mol. Cell. Endocrinol. |volume=126 |issue= 1 |pages= 75–81 |year= 1997 |pmid= 9027365 |doi=10.1016/S0303-7207(96)03971-8 }}
*{{cite journal  | author=Ota Y, Mariash A, Wagner JL, Mariash CN |title=Cloning, expression and regulation of the human S14 gene. |journal=Mol. Cell. Endocrinol. |volume=126 |issue= 1 |pages= 75-81 |year= 1997 |pmid= 9027365 |doi=  }}
*{{cite journal  | author=Taviaux S |title=Assignment of thyroid hormone responsive SPOT 14 homolog (THRSP) to human chromosome 11 bands q13.5→q14.1 by in situ hybridization |journal=Cytogenet. Cell Genet. |volume=76 |issue= 3–4 |pages= 219–20 |year= 1997 |pmid= 9186528 |doi=10.1159/000134553  |name-list-format=vanc| author2=Planells R  | author3=Gastaldi M  | display-authors=3  | last4=Torresani  | first4=J.  | last5=Grillasca  | first5=J.P. }}
*{{cite journal  | author=Taviaux S, Planells R, Gastaldi M, ''et al.'' |title=Assignment of thyroid hormone responsive SPOT 14 homolog (THRSP) to human chromosome 11 bands q13.5-->q14.1 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=76 |issue= 3-4 |pages= 219-20 |year= 1997 |pmid= 9186528 |doi=  }}
*{{cite journal  | author=Moncur JT |title=Assignment of the "spot 14" gene (THRSP) to human chromosome band 11q13.5 by in situ hybridization |journal=Cytogenet. Cell Genet. |volume=78 |issue= 2 |pages= 131–2 |year= 1997 |pmid= 9371405 |doi=10.1159/000134644  |name-list-format=vanc| author2=Park JP  | author3=Maloney M  | display-authors=3  | last4=Mohandas  | first4=T.K.  | last5=Kinlaw  | first5=W.B. }}
*{{cite journal  | author=Moncur JT, Park JP, Maloney M, ''et al.'' |title=Assignment of the "spot 14" gene (THRSP) to human chromosome band 11q13.5 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=78 |issue= 2 |pages= 131-2 |year= 1997 |pmid= 9371405 |doi=  }}
*{{cite journal  |vauthors=Cunningham BA, Maloney M, Kinlaw WB |title=Spot 14 protein-protein interactions: evidence for both homo- and heterodimer formation in vivo |journal=Endocrinology |volume=138 |issue= 12 |pages= 5184–8 |year= 1997 |pmid= 9389499 |doi=10.1210/en.138.12.5184 }}
*{{cite journal  | author=Cunningham BA, Maloney M, Kinlaw WB |title=Spot 14 protein-protein interactions: evidence for both homo- and heterodimer formation in vivo. |journal=Endocrinology |volume=138 |issue= 12 |pages= 5184-8 |year= 1997 |pmid= 9389499 |doi=  }}
*{{cite journal  | author=Moncur JT |title=The "Spot 14" gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: implications for control of tumor metabolism |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 12 |pages= 6989–94 |year= 1998 |pmid= 9618526 |doi=10.1073/pnas.95.12.6989  | pmc=22712  |name-list-format=vanc| author2=Park JP  | author3=Memoli VA  | display-authors=3  | last4=Mohandas  | first4=TK  | last5=Kinlaw  | first5=WB }}
*{{cite journal  | author=Moncur JT, Park JP, Memoli VA, ''et al.'' |title=The "Spot 14" gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: implications for control of tumor metabolism. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 12 |pages= 6989-94 |year= 1998 |pmid= 9618526 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Campbell MC, Anderson GW, Mariash CN |title=Human spot 14 glucose and thyroid hormone response: characterization and thyroid hormone response element identification |journal=Endocrinology |volume=144 |issue= 12 |pages= 5242–8 |year= 2004 |pmid= 12960053 |doi= 10.1210/en.2002-0008 }}
*{{cite journal  | author=Campbell MC, Anderson GW, Mariash CN |title=Human spot 14 glucose and thyroid hormone response: characterization and thyroid hormone response element identification. |journal=Endocrinology |volume=144 |issue= 12 |pages= 5242-8 |year= 2004 |pmid= 12960053 |doi= 10.1210/en.2002-0008 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Chou WY |title=Human spot 14 protein interacts physically and functionally with the thyroid receptor |journal=Biochem. Biophys. Res. Commun. |volume=357 |issue= 1 |pages= 133–8 |year= 2007 |pmid= 17418816 |doi= 10.1016/j.bbrc.2007.03.103 |name-list-format=vanc| author2=Cheng YS  | author3=Ho CL  | display-authors=3  | last4=Liu  | first4=Shu-Ting  | last5=Liu  | first5=Pei-Yao  | last6=Kuo  | first6=Chen-Chin  | last7=Chang  | first7=Hui-Ping  | last8=Chen  | first8=Yu-Hou  | last9=Chang  | first9=Gu-Gang }}
*{{cite journal  | author=Chou WY, Cheng YS, Ho CL, ''et al.'' |title=Human spot 14 protein interacts physically and functionally with the thyroid receptor. |journal=Biochem. Biophys. Res. Commun. |volume=357 |issue= 1 |pages= 133-8 |year= 2007 |pmid= 17418816 |doi= 10.1016/j.bbrc.2007.03.103 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 11:51, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Thyroid hormone-inducible hepatic protein is a protein that in humans is encoded by the THRSP gene.[1][2]

The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism.[2]

References

  1. ↑ Grillasca JP, Gastaldi M, Khiri H, Dace A, Peyrol N, Reynier P, Torresani J, Planells R (Feb 1997). "Cloning and initial characterization of human and mouse Spot 14 genes". FEBS Lett. 401 (1): 38–42. doi:10.1016/S0014-5793(96)01433-0. PMID 9003802.
  2. ↑ 2.0 2.1 "Entrez Gene: THRSP thyroid hormone responsive (SPOT14 homolog, rat)".

Further reading



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