TBC1D1: Difference between revisions

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{{Infobox_gene}}
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'''TBC1 domain family member 1''' is a [[protein]] that in humans is encoded by the ''TBC1D1'' [[gene]].<ref name="pmid10965142">{{cite journal | vauthors = White RA, Pasztor LM, Richardson PM, Zon LI | title = The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4 | journal = Cytogenet Cell Genet | volume = 89 | issue = 3-4 | pages = 272–5 |date=Sep 2000 | pmid = 10965142 | pmc =  | doi =10.1159/000015632 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23216| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
| HGNCid = 11578
| Symbol = TBC1D1
| AltSymbols =; KIAA1108; TBC; TBC1
| OMIM = 609850
| ECnumber =
| Homologene = 56856
| MGIid = 1889508
  | GeneAtlas_image1 = PBB_GE_TBC1D1_212350_at_tn.png
  | Function = {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}}  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23216
    | Hs_Ensembl = ENSG00000065882
    | Hs_RefseqProtein = NP_055988
    | Hs_RefseqmRNA = NM_015173
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 37569115
    | Hs_GenLoc_end = 37817189
    | Hs_Uniprot = Q86TI0
    | Mm_EntrezGene = 57915
    | Mm_Ensembl = ENSMUSG00000029174
    | Mm_RefseqmRNA = NM_019636
    | Mm_RefseqProtein = NP_062610
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 64438586
    | Mm_GenLoc_end = 64630615
    | Mm_Uniprot = Q148X0
  }}
}}
'''TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1''', also known as '''TBC1D1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23216| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23216| accessdate = }}</ref>
| summary_text = TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-[[amino acid]] [[TBC domain]] presumed to have a role in regulating [[cell growth]] and [[cell differentiation]]. These proteins share significant [[homology (biology)|homology]] with TRE2 (USP6; MIM 604334), [[Yeast expression platform|yeast]] Bub2, and [[CDC16]] (MIM 603461) (White et al., 2000).[supplied by OMIM]<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal   |vauthors=Nakajima D, Okazaki N, Yamakawa H, etal |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 }}
*{{cite journal  | author=Roach WG, Chavez JA, Mîinea CP, Lienhard GE |title=Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1. |journal=Biochem. J. |volume=403 |issue= 2 |pages= 353-8 |year= 2007 |pmid= 17274760 |doi= 10.1042/BJ20061798 }}
*{{cite journal  | vauthors=Roach WG, Chavez JA, Mîinea CP, Lienhard GE |title=Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1. |journal=Biochem. J. |volume=403 |issue= 2 |pages= 353–8 |year= 2007 |pmid= 17274760 |doi= 10.1042/BJ20061798 | pmc=1874243 }}
*{{cite journal | author=Stone S, Abkevich V, Russell DL, ''et al.'' |title=TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition. |journal=Hum. Mol. Genet. |volume=15 |issue= 18 |pages= 2709-20 |year= 2006 |pmid= 16893906 |doi= 10.1093/hmg/ddl204 }}
*{{cite journal   |vauthors=Stone S, Abkevich V, Russell DL, etal |title=TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition. |journal=Hum. Mol. Genet. |volume=15 |issue= 18 |pages= 2709–20 |year= 2006 |pmid= 16893906 |doi= 10.1093/hmg/ddl204 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal   |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal   |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal   |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=White RA, Pasztor LM, Richardson PM, Zon LI |title=The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4. |journal=Cytogenet. Cell Genet. |volume=89 |issue= 3-4 |pages= 272-5 |year= 2000 |pmid= 10965142 |doi= }}
*{{cite journal   |vauthors=Kikuno R, Nagase T, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=10.1093/dnares/6.3.197 }}
*{{cite journal | author=Kikuno R, Nagase T, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197-205 |year= 1999 |pmid= 10470851 |doi=  }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 11:38, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

TBC1 domain family member 1 is a protein that in humans is encoded by the TBC1D1 gene.[1][2]

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and cell differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000).[supplied by OMIM][2]

References

  1. ↑ White RA, Pasztor LM, Richardson PM, Zon LI (Sep 2000). "The gene encoding TBC1D1 with homology to the tre-2/USP6 oncogene, BUB2, and cdc16 maps to mouse chromosome 5 and human chromosome 4". Cytogenet Cell Genet. 89 (3–4): 272–5. doi:10.1159/000015632. PMID 10965142.
  2. ↑ 2.0 2.1 "Entrez Gene: TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1".

Further reading



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