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{{Addison's disease}}
{{Addison's disease}}


'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
{{CMG}} ; {{AE}} {{ADG}}
 
==Overview==
{{CMG}}
If left untreated, Addison's disease can be life-threatening. Complications of Addison's disease include [[hypoglycemia]], [[addisonian crisis]], [[hypoxia]], [[hypovolemic shock]], [[cardiac arrest]], [[stroke]]. Prognosis is generally good in patients with Addison's disease as long as they are on life time [[hormone replacement therapy]].


==Overview==
==Natural History==
If left untreated, Addison's disease can be life-threatening. Any stressful event or illness can cause a sudden worsening of [[symptoms]], which can lead to severe [[dehydration]] and fatally low [[blood pressure]] and eventually death.


==Natural History, Complications and Prognosis==
==Complications==
While treatment solutions for Addison's disease are far from precise, overall long-term prognosis is typically good. Because of individual physiological differences, each person with Addison's must work closely with their physician to adjust their medication dosage and schedule to find the most effective routine. Once this is accomplished (and occasional adjustments must be made from time to time, especially during periods of travel, stress, or other medical conditions), symptomology is usually greatly reduced or occasionally eliminated so long as the person continues their dosage schedule.
Complications of Addison's disease include:<ref name="pmid22907517">{{cite journal |vauthors=Quinkler M |title=[Addison's disease] |language=German |journal=Med Klin Intensivmed Notfmed |volume=107 |issue=6 |pages=454–9 |year=2012 |pmid=22907517 |doi=10.1007/s00063-012-0112-3 |url=}}</ref>
* [[Hypoglycemia]]
* [[Addisonian crisis]]
* [[Hypoxia]]
* [[Hypovolemic shock]]
* [[Cardiac arrest]]
* [[Stroke]]


==Prognosis==
*[[Prognosis]] is generally good in patients with Addison's disease as long as they are on life-time [[hormonal]] therapy.<ref name="pmid19011006">{{cite journal |vauthors=Erichsen MM, Løvås K, Fougner KJ, Svartberg J, Hauge ER, Bollerslev J, Berg JP, Mella B, Husebye ES |title=Normal overall mortality rate in Addison's disease, but young patients are at risk of premature death |journal=Eur. J. Endocrinol. |volume=160 |issue=2 |pages=233–7 |year=2009 |pmid=19011006 |doi=10.1530/EJE-08-0550 |url=}}</ref><ref name="pmid16968806">{{cite journal |vauthors=Bergthorsdottir R, Leonsson-Zachrisson M, Odén A, Johannsson G |title=Premature mortality in patients with Addison's disease: a population-based study |journal=J. Clin. Endocrinol. Metab. |volume=91 |issue=12 |pages=4849–53 |year=2006 |pmid=16968806 |doi=10.1210/jc.2006-0076 |url=}}</ref>
*Patients with Addison's disease must be closely monitored for [[Compliance (medicine)|compliance]] with medications as acute cases can be life-threating and the [[Mortality rate|mortality rates]] can go up to 95% in acute crisis.


==References==
==References==
{{reflist|2}}
{{Reflist|2}}
 
[[Category:Endocrinology]]
[[Category:Disease]]
[[Category:Medical emergencies]]
[[Category:Emergency medicine]]
[[Category:Intensive care medicine]]
[[Category:Needs overview]]


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Latest revision as of 16:46, 11 October 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]

Overview

If left untreated, Addison's disease can be life-threatening. Complications of Addison's disease include hypoglycemia, addisonian crisis, hypoxia, hypovolemic shock, cardiac arrest, stroke. Prognosis is generally good in patients with Addison's disease as long as they are on life time hormone replacement therapy.

Natural History

If left untreated, Addison's disease can be life-threatening. Any stressful event or illness can cause a sudden worsening of symptoms, which can lead to severe dehydration and fatally low blood pressure and eventually death.

Complications

Complications of Addison's disease include:[1]

Prognosis

  • Prognosis is generally good in patients with Addison's disease as long as they are on life-time hormonal therapy.[2][3]
  • Patients with Addison's disease must be closely monitored for compliance with medications as acute cases can be life-threating and the mortality rates can go up to 95% in acute crisis.

References

  1. Quinkler M (2012). "[Addison's disease]". Med Klin Intensivmed Notfmed (in German). 107 (6): 454–9. doi:10.1007/s00063-012-0112-3. PMID 22907517.
  2. Erichsen MM, Løvås K, Fougner KJ, Svartberg J, Hauge ER, Bollerslev J, Berg JP, Mella B, Husebye ES (2009). "Normal overall mortality rate in Addison's disease, but young patients are at risk of premature death". Eur. J. Endocrinol. 160 (2): 233–7. doi:10.1530/EJE-08-0550. PMID 19011006.
  3. Bergthorsdottir R, Leonsson-Zachrisson M, Odén A, Johannsson G (2006). "Premature mortality in patients with Addison's disease: a population-based study". J. Clin. Endocrinol. Metab. 91 (12): 4849–53. doi:10.1210/jc.2006-0076. PMID 16968806.

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