Zenker's diverticulum laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ajay Gade MD[2]]

Overview

Laboratory studies are not helpful in the diagnosis of the Zenker's Diverticulum (ZD), whereas they are used for the upper esophageal webs associated with iron deficiency anemia. The laboratory tests are done to differentiate the ZD from Plummer- Vinson syndrome. Laboratory findings consistent with the diagnosis of Plummer-Vinson syndrome include the presence of iron deficiency anemia.

Laboratory Findings

Laboratory studies are not helpful in the diagnosis of the ZD, whereas they are used for the upper esophageal webs associated with iron deficiency anemia. The laboratory tests is done to differentiate the ZD from Plummer- Vinson syndrome. Laboratory findings consistent with the diagnosis of Plummer-Vinson syndrome include presence of iron deficiency anemia:[1][2][3][4][5][6][7][8]

Complete blood count (CBC)

Complete blood count (CBC) should be done in patients with Plummer-Vinson syndrome and will have the following findings:

Iron studies

Iron studies should be done in patients with pallor, dysphagia or esophageal webs to confirm the diagnosis of Plummer-Vinson syndrome. The tests usually done for iron deficiency anemia are:

Change in lab values in iron deficiency anemia
Change Parameter
Decrease Hemoglobin, ferritin, mean corpuscular volume (MCV)
Increase TIBC, transferrin, red cell distribution width (RDW)

Peripheral smear

Peripheral smear may show:

Miscellaneous laboratory tests

References

  1. Guyatt G, Patterson C, Ali M, Singer J, Levine M, Turpie I, Meyer R (1990). "Diagnosis of iron-deficiency anemia in the elderly". Am J Med. 88 (3): 205–9. PMID 2178409.
  2. Hempel EV, Bollard ER (2016). "The Evidence-Based Evaluation of Iron Deficiency Anemia". Med. Clin. North Am. 100 (5): 1065–75. doi:10.1016/j.mcna.2016.04.015. PMID 27542426.
  3. Parkin PC, Maguire JL (2013). "Iron deficiency in early childhood". CMAJ. 185 (14): 1237–8. doi:10.1503/cmaj.130150. PMC 3787170. PMID 23922344.
  4. Mazza J, Barr RM, McDonald JW, Valberg LS (1978). "Usefulness of the serum ferritin concentration in the detection of iron deficiency in a general hospital". Can Med Assoc J. 119 (8): 884–6. PMC 1819106. PMID 737638.
  5. Thomason RW, Almiski MS (2009). "Evidence that stainable bone marrow iron following parenteral iron therapy does not correlate with serum iron studies and may not represent readily available storage iron". Am. J. Clin. Pathol. 131 (4): 580–5. doi:10.1309/AJCPBAY9KRZF8NUC. PMID 19289594.
  6. Kis AM, Carnes M (1998). "Detecting iron deficiency in anemic patients with concomitant medical problems". J Gen Intern Med. 13 (7): 455–61. PMC 1496985. PMID 9686711.
  7. Allali S, Brousse V, Sacri AS, Chalumeau M, de Montalembert M (2017). "Anemia in children: prevalence, causes, diagnostic work-up, and long-term consequences". Expert Rev Hematol: 1–6. doi:10.1080/17474086.2017.1354696. PMID 29023171.
  8. Liberti ME, Garofalo C, Sagliocca A, Borrelli S, Conte G, De Nicola L, Minutolo R (2017). "[Iron deficiency in ND-CKD: from diagnosis to treatment]". G Ital Nefrol (in Italian). 34 (5): 50–61. PMID 28963827.

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