Vitamin B12 deficiency history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

History and Symptoms

Early symptoms

  • Tiredness
  • Decreased mental work capacity
  • Decreased concentration and memory
  • Irritability and depression
  • Sleep disturbances because B12 involved in the regulation of the sleep wake cycle by the pineal gland (through melatonin).[1]

Neurological signs

References

  1. Hashimoto S, Kohsaka M, Morita N, Fukuda N, Honma S, Honma K (1996). "Vitamin B12 enhances the phase-response of circadian melatonin rhythm to a single bright light exposure in humans". Neurosci. Lett. 220 (2): 129–32. PMID 8981490.
  2. Sethi NK, Robilotti E, Sadan Y (2005). "Neurological Manifestations Of Vitamin B-12 Deficiency". The Internet Journal of Nutrition and Wellness. 2 (1).
  3. Masalha R, Chudakov B, Muhamad M, Rudoy I, Volkov I, Wirguin I (2001). "Cobalamin-responsive psychosis as the sole manifestation of vitamin B12 deficiency". Israeli Medical Association Journal. 3: 701–703.
  4. Reading CM. (1979). "X-linked dominant manic-depressive illness: Linkage with Xg blood-group, red-green color-blindness and vitamin-B12 deficiency". Orthomolecular Psychiatry. 8: 68–77.
  5. Reading CM. (1975). "Latent pernicious anemia: A preliminary report". Medical Journal of Australia. 40: 91–4.

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