UTS2

Urotensin 2
Identifiers
Symbols	UTS2 ; PRO1068; U-II; UCN2; UII
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4939
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE UTS2 220784 s at tn.png
File:PBB GE UTS2 220785 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Urotensin 2, also known as UTS2, is a human gene.

This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene.

Further reading

• Zhou P, Li ZL, Tang CS (2002). "Regulative effect of human urotensin-II on cardiovascular system". Di Yi Jun Yi Da Xue Xue Bao. 22 (6): 566–8. PMID 12297490.CS1 maint: Multiple names: authors list (link)
• Maguire JJ, Davenport AP (2003). "Is urotensin-II the new endothelin?". Br. J. Pharmacol. 137 (5): 579–88. doi:10.1038/sj.bjp.0704924. PMID 12381671.
• Balment RJ, Song W, Ashton N (2006). "Urotensin II: ancient hormone with new functions in vertebrate body fluid regulation". Ann. N. Y. Acad. Sci. 1040: 66–73. doi:10.1196/annals.1327.007. PMID 15891007.CS1 maint: Multiple names: authors list (link)
• Zhu YC, Zhu YZ, Moore PK (2006). "The role of urotensin II in cardiovascular and renal physiology and diseases". Br. J. Pharmacol. 148 (7): 884–901. doi:10.1038/sj.bjp.0706800. PMID 16783414.CS1 maint: Multiple names: authors list (link)
• Ashton N (2006). "Renal and vascular actions of urotensin II". Kidney Int. 70 (4): 624–9. doi:10.1038/sj.ki.5001621. PMID 16807543.
• Jaïs P, Terris B, Ruszniewski P; et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". Eur. J. Clin. Invest. 27 (8): 639–44. PMID 9279525.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Coulouarn Y, Lihrmann I, Jegou S; et al. (1999). "Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord". Proc. Natl. Acad. Sci. U.S.A. 95 (26): 15803–8. PMID 9861051.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ames RS, Sarau HM, Chambers JK; et al. (1999). "Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14". Nature. 401 (6750): 282–6. doi:10.1038/45809. PMID 10499587.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu Q, Pong SS, Zeng Z; et al. (2000). "Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14". Biochem. Biophys. Res. Commun. 266 (1): 174–8. doi:10.1006/bbrc.1999.1796. PMID 10581185.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zatelli MC, Tagliati F, Taylor JE; et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". J. Clin. Endocrinol. Metab. 86 (5): 2161–9. PMID 11344221.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matsushita M, Shichiri M, Imai T; et al. (2002). "Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues". J. Hypertens. 19 (12): 2185–90. PMID 11725162.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Valdez GR, Inoue K, Koob GF; et al. (2002). "Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide". Brain Res. 943 (1): 142–50. PMID 12088848.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kinney WA, Almond Jr HR, Qi J; et al. (2002). "Structure-function analysis of urotensin II and its use in the construction of a ligand-receptor working model". Angew. Chem. Int. Ed. Engl. 41 (16): 2940–4. doi:10.1002/1521-3773(20020816)41:16<2940::AID-ANIE2940>3.0.CO;2-M. PMID 12203418.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dschietzig T, Bartsch C, Pregla R; et al. (2003). "Plasma levels and cardiovascular gene expression of urotensin-II in human heart failure". Regul. Pept. 110 (1): 33–8. PMID 12468107.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhu F, Ji L, Luo B (2003). "[The role of urotensin II gene in the genetic susceptibility to type 2 diabetes in Chinese population]". Zhonghua Yi Xue Za Zhi. 82 (21): 1473–5. PMID 12509909.CS1 maint: Multiple names: authors list (link)
• Russell FD, Meyers D, Galbraith AJ; et al. (2003). "Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure". Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1576–81. doi:10.1152/ajpheart.00217.2003. PMID 12791592.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wenyi Z, Suzuki S, Hirai M; et al. (2004). "Role of urotensin II gene in genetic susceptibility to Type 2 diabetes mellitus in Japanese subjects". Diabetologia. 46 (7): 972–6. doi:10.1007/s00125-003-1145-1. PMID 12830381.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)