Ubiquitin specific peptidase 18 (USP18), also known as UBP43, is an isopeptidase that in human is encoded by the USP18 gene.[1] USP18 is a member of the deubiquitinating protease family of enzymes. It is thought to remove ISG15 adducts from a broad range of protein substrates, a process known as deISGylation.[1] In mice, deletion of this enzyme results in increased inflammatory response to type I interferons, suggesting that USP18 may, in part, regulate interferon responsiveness.[2]
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