Triple Negative Breast Cancer
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Overview
It is now commonly understood that breast cancer is not one form of cancer, but many different "subtypes" of cancer.[2] [3] These subtypes of breast cancer are generally diagnosed based upon the presence, or lack of, three "receptors" known to fuel most breast cancers: estrogen receptors, progesterone receptors and human epidermal growth factor receptor 2 (HER2).[4] The most successful treatments for breast cancer target these receptors.[5]
Unfortunately, none of these receptors are found in women with triple negative breast cancer. A triple negative breast cancer diagnosis means that the offending tumor is estrogen receptor-negative, progesterone receptor-negative and HER2-negative, thus giving rise to the name "triple negative breast cancer."[6][7] On a positive note, this type of breast cancer is typically responsive to chemotherapy.[8] Because of its triple negative status, however, triple negative tumors generally do not respond to receptor targeted treatments.[9][10] Depending on the stage of its diagnosis, triple negative breast cancer can be particularly aggressive, and more likely to recur than other subtypes of breast cancer.[11][12][13]
Triple negative breast cancer accounts for approximately 15% of all breast cancer cases.[14] It occurs most often in African American and younger women.[15][16] [17][18] Because it is a recently recognized form of breast cancer, there is very little known about its pathology.[19] Thus, there is an urgent need for targeted research and better treatment options for this disease.[20]
See also
Triple Negative Breast Cancer Foundation
External links
- The Official Triple Negative Breast Cancer Foundation Site
- Triple Negative Breast Cancer Discussion Forum
- Information about Triple Negative Breast Cancer
- Susan G. Komen for the Cure
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
