Trichlorfon

Jump to navigation Jump to search
Metrifonate
Clinical data
SynonymsTrichlorphon
AHFS/Drugs.comInternational Drug Names
ATC code
Pharmacokinetic data
Elimination half-life3 hours
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC4H8Cl3O4P
Molar mass257.436 g/mol
3D model (JSmol)
  (verify)

WikiDoc Resources for Trichlorfon

Articles

Most recent articles on Trichlorfon

Most cited articles on Trichlorfon

Review articles on Trichlorfon

Articles on Trichlorfon in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Trichlorfon

Images of Trichlorfon

Photos of Trichlorfon

Podcasts & MP3s on Trichlorfon

Videos on Trichlorfon

Evidence Based Medicine

Cochrane Collaboration on Trichlorfon

Bandolier on Trichlorfon

TRIP on Trichlorfon

Clinical Trials

Ongoing Trials on Trichlorfon at Clinical Trials.gov

Trial results on Trichlorfon

Clinical Trials on Trichlorfon at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Trichlorfon

NICE Guidance on Trichlorfon

NHS PRODIGY Guidance

FDA on Trichlorfon

CDC on Trichlorfon

Books

Books on Trichlorfon

News

Trichlorfon in the news

Be alerted to news on Trichlorfon

News trends on Trichlorfon

Commentary

Blogs on Trichlorfon

Definitions

Definitions of Trichlorfon

Patient Resources / Community

Patient resources on Trichlorfon

Discussion groups on Trichlorfon

Patient Handouts on Trichlorfon

Directions to Hospitals Treating Trichlorfon

Risk calculators and risk factors for Trichlorfon

Healthcare Provider Resources

Symptoms of Trichlorfon

Causes & Risk Factors for Trichlorfon

Diagnostic studies for Trichlorfon

Treatment of Trichlorfon

Continuing Medical Education (CME)

CME Programs on Trichlorfon

International

Trichlorfon en Espanol

Trichlorfon en Francais

Business

Trichlorfon in the Marketplace

Patents on Trichlorfon

Experimental / Informatics

List of terms related to Trichlorfon

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Metrifonate (INN) or trichlorfon (USAN) is an irreversible organophosphate acetylcholinesterase inhibitor.[1] It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate (DDVP).

It is used as an insecticide.

It can be used to treat schistosomiasis caused by Schistoma haematobium but is no longer commercially available.[2]

It has been proposed for use in treatment of Alzheimer's disease, but use for that purpose is not currently recommended.[3]

References

  1. "NLH - Neurological Conditions - Metrifonate for Alzheimer's disease".
  2. Ross A.G.P., Bartley P.B., Sleigh A.C., Olds G.R., Li Y., Williams G.M., and McManus D.P. (2002). "Schistosomiasis". The New England Journal of Medicine. 346 (16): 1212–1220. doi:10.1056/NEJMra012396. PMID 11961151.
  3. López-Arrieta J, Schneider L (2008). López-Arrieta, Jess, ed. "Metrifonate for Alzheimer's disease". Cochrane Database of Systematic Reviews (1): CD003155. doi:10.1002/14651858.CD003155.pub3. PMID 16625573.

Template:Anthelmintics