Transmetalation

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Overview

Transmetalation (alt. spelling: transmetallation) is a general chemical reaction type in organometallic chemistry describing the exchange of ligands between two metal centers.

transmetallation

The metal centers need not be the same. The ligands R and R' can be organic or inorganic. The double displacement reaction is conceptually related.

Transmetalation is important in the synthesis of various organometallic compounds. Silver N-heterocyclic carbene complexes are easily formed, and are often used to transfer the carbene ligands to other metals containing labile ligands such as acetonitrile or 1,5-cyclooctadiene.[1] Where L-H+ denotes the ligand precursor:

2 L-H+ + Ag2O → L2Ag+...AgX- (X = ligand precursor counteranion)
L-Ag...AgX + PdCl2MeCN2 → PdL2Cl2

This reaction type also appears frequently in the catalytic cycle of various metal catalysed organic reactions such as the Stille reaction and the Negishi coupling.

References

  1. Wang, H. M. J., Lin, I. J. B. (1998). "Facile Synthesis of Silver(I)-Carbene Complexes. Useful Carbene Transfer Agents". Organometallics. 17 (5): 972–975. doi:10.1021/om9709704.



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