Trans-octaprenyltranstransferase

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In enzymology, a trans-octaprenyltranstransferase (EC 2.5.1.11) is an enzyme that catalyzes the chemical reaction

all-trans-octaprenyl diphosphate + isopentenyl diphosphate diphosphate + all-trans-nonaprenyl diphosphate

Thus, the two substrates of this enzyme are all-trans-octaprenyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and all-trans-nonaprenyl diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is (E)-octaprenyl-diphosphate:isopentenyl-diphosphate octaprenyltranstransferase. Other names in common use include all-trans-nonaprenyl-diphosphate synthase, solanesyl-diphosphate synthase, solanesyl pyrophosphate synthetase, SPP synthase, nonaprenyl pyrophosphate synthetase, polyprenylpyrophosphate synthetase, terpenoidallyltransferase, terpenyl pyrophosphate synthetase, trans-octaprenyltranstransferase, and trans-prenyltransferase. This enzyme participates in biosynthesis of steroids.

Structural studies

As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes 1V4E, 1V4H, 1V4I, 1V4J, 1V4K, 1VG2, 1VG3, 1VG4, 1VG6, 1VG7, 1WKZ, 1WL0, 1WL1, 1WL2, 1WL3, and 2AZL.

References

  • IUBMB entry for 2.5.1.11
  • BRENDA references for 2.5.1.11 (Recommended.)
  • PubMed references for 2.5.1.11
  • PubMed Central references for 2.5.1.11
  • Google Scholar references for 2.5.1.11
  • Fujii H, Sagami H, Koyama T, Ogura K, Seto S, Baba T, Allen CM (1980). "Variable product specificity of solanesyl pyrophosphate synthetase". Biochem. Biophys. Res. Commun. 96: 1648&ndash, 53. PMID 7447947.
  • Sagami H, Ogura K and Seto S (1978). "Solanesyl pyrophosphate synthetase from Micrococcus lysodeikticus". Biochemistry. 16: 4616&ndash, 4622.

External links

The CAS registry number for this enzyme class is 64763-52-6.

Gene Ontology (GO) codes


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