Tramadol overdose
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overdosage topics
General
A single or multiple overdose with Tramadol may be a potentially lethal polydrug overdose, and consultation with a regional poison control center is recommended. Return to top
Treatment
In treating an overdose of Tramadol, primary attention should be given to maintaining adequate
ventilation along with general supportive treatment. While naloxone will reverse some, but not all,
symptoms caused by overdosage with tramadol, the risk of seizures is also increased with naloxone
administration. In animals, convulsions following the administration of toxic doses of tramadol could
be suppressed with barbiturates or benzodiazepines but were increased with naloxone. Naloxone
administration did not change the lethality of an overdose in mice. Based on experience with tramadol,
hemodialysis is not expected to be helpful in an overdose because it removes less than 7% of the
administered dose in a 4-hour dialysis period. Return to top
Adapted from the FDA Package Insert.