Thymidine phosphorylase

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In enzymology, a thymidine phosphorylase (EC 2.4.2.4) is an enzyme that catalyzes the chemical reaction

thymidine + phosphate thymine + 2-deoxy-alpha-D-ribose 1-phosphate

Thus, the two substrates of this enzyme are thymidine and phosphate, whereas its two products are thymine and 2-deoxy-alpha-D-ribose 1-phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is thymidine:phosphate deoxy-alpha-D-ribosyltransferase. Other names in common use include pyrimidine phosphorylase, thymidine-orthophosphate deoxyribosyltransferase, animal growth regulators, blood platelet-derived endothelial cell, growth factors, blood platelet-derived endothelial cell growth factor, deoxythymidine phosphorylase, gliostatins, pyrimidine deoxynucleoside phosphorylase, and thymidine:phosphate deoxy-D-ribosyltransferase. This enzyme participates in 3 metabolic pathways: purine metabolism, pyrimidine metabolism, and bladder cancer.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1AZY, 1OTP, 1TPT, 1UOU, 2J0F, and 2TPT.

References

  • IUBMB entry for 2.4.2.4
  • BRENDA references for 2.4.2.4 (Recommended.)
  • PubMed references for 2.4.2.4
  • PubMed Central references for 2.4.2.4
  • Google Scholar references for 2.4.2.4
  • FRIEDKIN M, ROBERTS D (1954). "The enzymatic synthesis of nucleosides. I. Thymidine phosphorylase in mammalian tissue". J. Biol. Chem. 207: 245&ndash, 56. PMID 13152099.
  • Zimmerman M and Seidenberg J (1964). "Deoxyribosyl transfer. I. Thymidine phosphorylase and nucleoside deoxyribosyltransferase in normal and malignant tissues". J. Biol. Chem. 239: 2618&ndash, 2621.
  • Zimmerman M (1964). "Deoxyribosyl transfer. II. Nucleoside:pyrimidine deoxyribosyltransferase activity of three partially purified thymidine phosphorylases". J. Biol. Chem. 239: 2622&ndash, 2627.

External links

The CAS registry number for this enzyme class is 9030-23-3.

Gene Ontology (GO) codes


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