Thrombospondin 3

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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RefSeq (protein)

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Thrombospondin-3 (TSP3) is a protein that in humans is encoded by the THBS3 gene.[1][2]

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. TSP3 has been found to be involved in the regulation of skeletal maturation.[3] This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1.[2]

References

  1. Vos HL, Devarayalu S, de Vries Y, Bornstein P (Jul 1992). "Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family". J Biol Chem. 267 (17): 12192–6. PMID 1601886.
  2. 2.0 2.1 "Entrez Gene: THBS3 thrombospondin 3".
  3. Hankenson, Kurt (July 2005). "Mice with a Disruption of the Thrombospondin 3 Gene Differ in Geometric and Biomechanical Properties of Bone and Have Accelerated Development of the Femoral Head". Molecular and Cellular Biology. 25 (13): 5599–5606. doi:10.1128/MCB.25.13.5599-5606.2005. PMC 1156967. PMID 15964815. Retrieved 24 February 2015.

Further reading