Threose nucleic acid
DNA and RNA have a deoxyribose and ribose sugar backbone, respectively, whereas TNA's backbone is composed of repeating threose units linked by phosphodiester bonds. The threose molecule is easier to assemble than ribose making it a possible precursor to RNA.
DNA-TNA hybrid chains have been made in the laboratory using DNA polymerase.
TNA can specifically base pair with RNA and DNA, this capability and chemical simplicity suggests that TNA could have preceded RNA as genetic material.
- Was simple TNA the first nucleic acid on Earth to carry a genetic code? - New scientist
- ORIGIN OF LIFE: A Simpler Nucleic Acid - Leslie Orgel
- Orgel, Leslie (2000). "A Simpler Nucleic Acid". Science. 290 (5495): 1306–1307. doi:10.1126/science.290.5495.1306. Unknown parameter
- Watt, Gregory (2005). "Modified nucleic acids on display". Nature Chemical Biology. doi:10.1038/nchembio005. Unknown parameter
- Schoning, K (2000). "Chemical etiology of nucleic acid structure: the alpha-threofuranosyl-(3'->2') oligonucleotide system". Science. PMID 11082060. Unknown parameter
|month=ignored (help); Unknown parameter
|40x30px||This genetics article is a stub. You can help Wikipedia by expanding it.|