TGFBR2

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Transforming growth factor, beta receptor II (70/80kDa)
File:PBB Protein TGFBR2 image.jpg
PDB rendering based on 1ktz.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols TGFBR2 ; AAT3; FAA3; HNPCC6; MFS2; RIIC; TAAD2; TGFR-2; TGFbeta-RII
External IDs Template:OMIM5 Template:MGI HomoloGene2435
RNA expression pattern
File:PBB GE TGFBR2 208944 at tn.png
File:PBB GE TGFBR2 207334 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Transforming growth factor, beta receptor II (70/80kDa), also known as TGFBR2, is a human gene.

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.[1]

See also

References

  1. "Entrez Gene: TGFBR2 transforming growth factor, beta receptor II (70/80kDa)".

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