Transcription Factor II H

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general transcription factor IIH, polypeptide 1, 62kDa
Identifiers
SymbolGTF2H1
Alt. symbolsBTF2
Entrez2965
HUGO4655
OMIM189972
RefSeqNM_005316
UniProtP32780
Other data
LocusChr. 11 p15.1-p14
general transcription factor IIH, polypeptide 2, 44kDa
Identifiers
SymbolGTF2H2
Alt. symbolsBTF2, TFIIH, BTF2P44, T-BTF2P44
Entrez2966
HUGO4656
OMIM601748
RefSeqNM_001515
UniProtQ13888
Other data
LocusChr. 5 q12.2-13.3
general transcription factor IIH, polypeptide 3, 34kDa
Identifiers
SymbolGTF2H3
Alt. symbolsBTF2, TFIIH
Entrez2967
HUGO4657
OMIM601750
RefSeqNM_001516
UniProtQ13889
Other data
LocusChr. 12 q24.31

TFIIH is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. TFIIH contains a number of subunits with different functions.[1] Two of the subunits, ERCC2/XPD and ERCC3/XPB, have helicase activity and help create the transcription bubble. In a test tube these subunits are only required for transcription if the DNA template is not already denatured or supercoiled. Two other TFIIH subunits, CDK7 and cyclin H, phosphorylate serine amino acids on the RNA polymerase II C-terminal domain and possibly other proteins involved in the cell cycle.


References

  1. Lee TI, Young RA (2000). "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. doi:10.1146/annurev.genet.34.1.77. PMID 11092823.

External links


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