Syntaphilin

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Syntaphilin is a protein that in humans is encoded by the SNPH gene.

Function

Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Expression of this gene appears to be brain-specific. Alternative splicing results in multiple transcript variants encoding different isoforms.

Further reading

• Das S, Gerwin C, Sheng ZH (2003). "Syntaphilin binds to dynamin-1 and inhibits dynamin-dependent endocytosis". J. Biol. Chem. 278 (42): 41221–6. doi:10.1074/jbc.M304851200. PMID 12896979.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.