Sulforaphane

(Redirected from Sulphoraphane)
Jump to navigation Jump to search

Template:Chembox new

WikiDoc Resources for Sulforaphane

Articles

Most recent articles on Sulforaphane

Most cited articles on Sulforaphane

Review articles on Sulforaphane

Articles on Sulforaphane in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Sulforaphane

Images of Sulforaphane

Photos of Sulforaphane

Podcasts & MP3s on Sulforaphane

Videos on Sulforaphane

Evidence Based Medicine

Cochrane Collaboration on Sulforaphane

Bandolier on Sulforaphane

TRIP on Sulforaphane

Clinical Trials

Ongoing Trials on Sulforaphane at Clinical Trials.gov

Trial results on Sulforaphane

Clinical Trials on Sulforaphane at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Sulforaphane

NICE Guidance on Sulforaphane

NHS PRODIGY Guidance

FDA on Sulforaphane

CDC on Sulforaphane

Books

Books on Sulforaphane

News

Sulforaphane in the news

Be alerted to news on Sulforaphane

News trends on Sulforaphane

Commentary

Blogs on Sulforaphane

Definitions

Definitions of Sulforaphane

Patient Resources / Community

Patient resources on Sulforaphane

Discussion groups on Sulforaphane

Patient Handouts on Sulforaphane

Directions to Hospitals Treating Sulforaphane

Risk calculators and risk factors for Sulforaphane

Healthcare Provider Resources

Symptoms of Sulforaphane

Causes & Risk Factors for Sulforaphane

Diagnostic studies for Sulforaphane

Treatment of Sulforaphane

Continuing Medical Education (CME)

CME Programs on Sulforaphane

International

Sulforaphane en Espanol

Sulforaphane en Francais

Business

Sulforaphane in the Marketplace

Patents on Sulforaphane

Experimental / Informatics

List of terms related to Sulforaphane

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Sulforaphane is an anticancer and antimicrobial compound that can be obtained by eating cruciferous vegetables such as brussel sprouts, broccoli, cabbage, cauliflower, bok choy, kale, collards, broccoli sprouts, chinese broccoli, broccoli raab, kohlrabi, mustard, turnip, radish, rocket, and watercress. The enzyme myrosinase transforms glucoraphanin (a glucosinolate) into sulforaphane upon damage to the plant (such as from chewing). The young sprouts of broccoli and cauliflower are particularly rich in glucoraphanin.

The anticancer activity of sulforaphane is thought to be related to the induction of phase-II enzymes of xenobiotic transformation (such as quinone reductase and glutathione S-transferase), and enhancing the transcription of tumor suppressor proteins.[citation needed]

File:Sulforaphane.png
Structural formula

Researchers at the Johns Hopkins University School of Medicine in Baltimore MD first identified sulforaphane in broccoli sprouts [1] which, of the cruciferous vegetables, have the highest concentration of sulforaphane. Consumption of broccoli sprouts has shown to be effective at inhibiting Helicobacter pylori growth[2] with sulforaphane being at least one of the active agents[3].

Sulforaphane and Diindolylmethane (another compound from Brassica vegetables) have recently been shown to synergize together in the inhibition of cancer growth.

In terms of dosage, optimal levels have not yet been determined but some doctors recommend 200 - 400 mcg of sulforaphane daily from broccoli-sprout extracts. Despite that no side effects or drug interactions have been reported yet, people taking prescription drugs are still advised to consult a doctor before taking sulforaphane or broccoli-sprout extracts. Sulforaphane and dietary consumption of cruciferous vegetables are known to affect the action of drug-detoxifying enzymes.[4]

Sulforaphane seems to protect skin against UV radiation damage, and thus potentially against cancer, when applied topically. [5]

File:Glucoraphanin.png
glucoraphanin
File:Sulforaphane.png
(-)-(R)-sulforaphane

Notes

  1. Zhang Y, Talalay P, Cho CG, Posner GH. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci 1992;89:2399–403
  2. Galan MV, Kishan AA, Silverman AL (2004). "Oral broccoli sprouts for the treatment of Helicobacter pylori infection: a preliminary report". Dig Dis Sci. 49 (7–8): 1088–90. PMID 15387326. Unknown parameter |month= ignored (help)
  3. Fahey JW, Haristoy X, Dolan PM, Kensler TW, Scholtus I, Stephenson KK, Talalay P, Lozniewski A (2002). "Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors". PMID 12032331. Unknown parameter |month= ignored (help)
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett 1997;114:169–70.
  5. Talalay P, Fahey JW, Healy ZR, Wehage SL, Benedict AL, Min C, Dinkova-Kostova AT. Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation. Proc Natl Acad Sci U S A. 2007 Oct 23; [Epub ahead of print].

Template:Glycosides

de:Sulforaphan nl:Sulforafaan sl:Sulforafan Template:WH Template:WS