Balo concentric sclerosis

Jump to: navigation, search

WikiDoc Resources for Balo concentric sclerosis

Articles

Most recent articles on Balo concentric sclerosis

Most cited articles on Balo concentric sclerosis

Review articles on Balo concentric sclerosis

Articles on Balo concentric sclerosis in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Balo concentric sclerosis

Images of Balo concentric sclerosis

Photos of Balo concentric sclerosis

Podcasts & MP3s on Balo concentric sclerosis

Videos on Balo concentric sclerosis

Evidence Based Medicine

Cochrane Collaboration on Balo concentric sclerosis

Bandolier on Balo concentric sclerosis

TRIP on Balo concentric sclerosis

Clinical Trials

Ongoing Trials on Balo concentric sclerosis at Clinical Trials.gov

Trial results on Balo concentric sclerosis

Clinical Trials on Balo concentric sclerosis at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Balo concentric sclerosis

NICE Guidance on Balo concentric sclerosis

NHS PRODIGY Guidance

FDA on Balo concentric sclerosis

CDC on Balo concentric sclerosis

Books

Books on Balo concentric sclerosis

News

Balo concentric sclerosis in the news

Be alerted to news on Balo concentric sclerosis

News trends on Balo concentric sclerosis

Commentary

Blogs on Balo concentric sclerosis

Definitions

Definitions of Balo concentric sclerosis

Patient Resources / Community

Patient resources on Balo concentric sclerosis

Discussion groups on Balo concentric sclerosis

Patient Handouts on Balo concentric sclerosis

Directions to Hospitals Treating Balo concentric sclerosis

Risk calculators and risk factors for Balo concentric sclerosis

Healthcare Provider Resources

Symptoms of Balo concentric sclerosis

Causes & Risk Factors for Balo concentric sclerosis

Diagnostic studies for Balo concentric sclerosis

Treatment of Balo concentric sclerosis

Continuing Medical Education (CME)

CME Programs on Balo concentric sclerosis

International

Balo concentric sclerosis en Espanol

Balo concentric sclerosis en Francais

Business

Balo concentric sclerosis in the Marketplace

Patents on Balo concentric sclerosis

Experimental / Informatics

List of terms related to Balo concentric sclerosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [8] Synonyms and Keywords: Sudanophilic cerebral sclerosis; diffuse sclerosis of Schilder; encephalitis periaxalis diffusa; myelinoclastic diffuse sclerosis

Overview

Balo concentric sclerosis is one of the borderline forms of multiple sclerosis.Balo concentric sclerosis is a demyelinating disease similar to standard Multiple sclerosis, but with the particularity that the demyelinated tissues form concentric layers. Scientists used to believe that the prognosis was similar to Marburg multiple sclerosis, but now they know that patients can survive, or even have spontaneous remission and asymptomatic cases.[1]

It is also common that the clinic course is primary progressive, but a relapsing-remitting course has been reported. [2]It seems that the course gets better with prednisone therapy[3], although evidence of this is anecdotal and such conclusions are difficult to accept given that there are cases where patients spontaneously recover whether the patient was on steroid therapy or not.

Historical Perspective

Classification

Pathophysiology

The lesions of the Balo sclerosis belong to the MS lesion pattern III (distal oligodendrogliopathy).[4]

According with Dr. Lucchinetti investigations, in Balo's concentric sclerosis, the rings may be caused by a physiological hypoxia (similar to that caused by some toxins or viruses) in the lesion, which is in turn countered by expression of stress proteins at the border. This expression and counter-expression forms rings of preserved tissue within the lesion and rings of demyelinated tissue just beyond where the previous attack had induced the protective stress proteins. Hence, subsequent attacks form concentric rings. [5].

Ultimately, this expanding lesion causes the progressive picture typically seen. However, in some patients, the pathology underlying the disease appears to burn out and hence the disease may halt, hence the patients who spontaneously recover. The mechanisms triggering attacks and recovery remain uncertain.

Recently, a mathematical model for concentric sclerosis has been proposed[6]. Authors review the previous pathogenic theories, discuss the link between concentric sclerosis and Liesegang's periodic precipitation phenomenon and propose a new mechanism based on self-organization.

Differentiating Balo Concentric Sclerosis from other Diseases

Epidemiology and Demographics

The disease is more common in Chinese and Filipino populations (both Asiatic) than in caucasoids[7].

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

Symptoms

Physical Examination

Laboratory Findings

Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Prevention

Related Chapters

References

  1. Baló's Concentric Sclerosis: Clinical and Radiologic Features of Five Cases [1]
  2. Balo's concentric sclerosis: surviving normal myelin in a patient with a relapsing-remitting clinical course[2]
  3. Balo's concentric demyelination diagnosed premortem [3]
  4. (Article in Spanish) [4]
  5. Genetic susceptibility in MS – Steve Hauser. Rare Neuroimmunologic Disorders Symposium [5]
  6. The Origins of Concentric Demyelination: Self-Organization in the Human Brain, Khonsari & Calvez, PLoS ONE 2(1):e150)[6]
  7. Article at mult-sclerosis.org [7]



Linked-in.jpg