Strongyloidiasis other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]

Overview

Upper and lower GI endoscopy, skin biopsy, and BAL fluid examination are some other diagnostic tests that are employed in diagnosing strongyloidiasis when there is a negative stool exam.

Other diagnostic tests

Upper and lower GI endoscopy, skin biopsy, and BAL fluid examination are some other diagnostic tests that are employed in diagnosing strongyloidiasis when there is a negative stool exam.

Test	Findings
Upper GI endoscopy	Typically worms are found in the proximal part of the small intestine Edematous and erythematous mucosa with larva on biopsy
BAL/ Sputum examination	Larvae can be detected by simple wet-mount in fluid collected by BAL
Skin biopsy	Obtain specimens from the purpuric eruptions Edema, extravasated red blood cells (RBCs), and some lymphocytes in the superficial dermis. The larvae range in size from 9 to 15 µm.
CSF (CNS involvement)	Findings similar to bacterial meningitis Negative gram stain A wet mount preparation may reveal S stercoralis larvae.
Duodenal aspiration	Duodenal aspirate is more sensitive than stool examination, and duodenal biopsy may reveal parasites in the gastric crypts, in the duodenal glands, or eosinophilic infiltration in the lamina propria. The duodenal fluid can be examined using techniques such as the Enterotest string or duodenal aspiration.​