Sodium-glucose co-transporter 2

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solute carrier family 5 (sodium/glucose cotransporter), member 2
Identifiers
SymbolSLC5A2
Alt. symbolsSGLT2
Entrez6524
HUGO11037
OMIM182381
RefSeqNM_003041
UniProtP31639
Other data
LocusChr. 16 p11.2

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Overview

Sodium-dependent glucose cotrasporter 2 are a family of glucose transporter "expressed in the luminal membrane of the proximal kidney tubules"[1]. They contribute to renal glucose reabsorption.

Pharmacology

Inhibitors

  • Canagliflozin
  • Dapagliflozin
  • Empagliflozin
  • Gliflozin

Inhibitors improve glycemic control[2] and may reduce clinical outcomes[3].

References

  1. Anonymous 2015, co-transporter 2 Sodium-glucose co-transporter 2. Medical Subject Headings. U.S. National Library of Medicine.
  2. Vasilakou D, Karagiannis T, Athanasiadou E, Mainou M, Liakos A, Bekiari E; et al. (2013). "Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysis". Ann Intern Med. 159 (4): 262–74. doi:10.7326/0003-4819-159-4-201308200-00007. PMID 24026259. Review in: Ann Intern Med. 2014 Jan 21;160(2):JC10
  3. Zinman B, Wanner C, Lachin JM, Fitchett D, Bluhmki E, Hantel S; et al. (2015). "Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes". N Engl J Med. doi:10.1056/NEJMoa1504720. PMID 26378978.

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