Sinusoidal obstruction syndrome classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Husnain Shaukat, M.D [2]

Overview

There is no established system for the classification of sinusoidal obstruction syndrome. However, it can be classified on the basis of severity as mild, moderate and severe.

Classification

There is no established system for the classification of sinusoidal obstruction syndrome. However, it can be classified on the basis of severity as mild, moderate and severe.[1]

Parameters Mild Moderate Severe
Serum total bilirubin
  • <5 mg/dL
  • < (5.1 to 8 mg/dL
  • >8 mg/dL
Serum aspartate aminotransferase (AST)
  • <3 x normal
  • 3 to 8 x normal
  • >8 x normal
Weight above baseline
  • <2 percent
  • 2 to 5 percent
  • >5 percent
Serum creatinine
  • Normal
  • <2 x normal
  • >2 x normal
Rate of change Slow (over 6–7 d) (over 4–5 d) Rapid (over2–3 d)

References

  1. Chao N (2014). "How I treat sinusoidal obstruction syndrome". Blood. 123 (26): 4023–6. doi:10.1182/blood-2014-03-551630. PMID 24833355.



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