Serglycin

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serglycin, also known as hematopoetic proteoglycan core protein or secretory granule proteoglycan core protein, is a protein that in humans is encoded by the SRGN gene.[1] It is primarily expressed in hematopoietic cells and endothelial cells.[2]

Function

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis.[1]

References

  1. 1.0 1.1 "Entrez Gene: SRGN serglycin".
  2. Kolset, SO; Tveit, H (April 2008). "Serglycin--structure and biology". Cellular and molecular life sciences : CMLS. 65 (7–8): 1073–85. doi:10.1007/s00018-007-7455-6. PMID 18066495.

Further reading