SHC3

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Identifiers
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External IDs	GeneCards: [1]
Orthologs
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	Wikidata
View/Edit Human

SHC-transforming protein 3 is a protein that in humans is encoded by the SHC3 gene.^[1]^[2]

Interactions

SHC3 has been shown to interact with RICS^[3] and TrkB.^[4]^[5]

References

↑ Nakamura T; Sanokawa R; Sasaki Y; Ayusawa D; Oishi M; Mori N (November 1996). "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway". Oncogene. 13 (6): 1111–21. PMID 8808684.
↑ "Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3".
↑ Nakamura, Takeshi; Komiya Misako; Sone Kiyoaki; Hirose Eiji; Gotoh Noriko; Morii Hiroshi; Ohta Yasutaka; Mori Nozomu (December 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Mol. Cell. Biol. United States. 22 (24): 8721–34. doi:10.1128/MCB.22.24.8721-8734.2002. ISSN 0270-7306. PMC 139861. PMID 12446789.
↑ Nakamura, T; Muraoka S; Sanokawa R; Mori N (March 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J. Biol. Chem. UNITED STATES. 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. ISSN 0021-9258. PMID 9507002.
↑ Suzuki, Shingo; Mizutani Masaharu; Suzuki Kenji; Yamada Masashi; Kojima Masami; Hatanaka Hiroshi; Koizumi Shinichi (June 2002). "Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor". Biochem. Biophys. Res. Commun. United States. 294 (5): 1087–92. doi:10.1016/S0006-291X(02)00606-X. ISSN 0006-291X. PMID 12074588.

O'Bryan JP, Songyang Z, Cantley L, et al. (1996). "A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain". Proc. Natl. Acad. Sci. U.S.A. 93 (7): 2729–34. Bibcode:1996PNAS...93.2729O. doi:10.1073/pnas.93.7.2729. PMC 39699. PMID 8610109.
Pelicci G, Dente L, De Giuseppe A, et al. (1996). "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions". Oncogene. 13 (3): 633–41. PMID 8760305.
Menegon A; Leoni C; Benfenati F; Valtorta F (1997). "Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum". Biochem. Biophys. Res. Commun. 238 (3): 800–5. doi:10.1006/bbrc.1997.7393. PMID 9325171.
Wang JF, Ganju RK, Liu ZY, et al. (1997). "Signal transduction in human hematopoietic cells by vascular endothelial growth factor related protein, a novel ligand for the FLT4 receptor". Blood. 90 (9): 3507–15. PMID 9345034.
Nakamura T; Muraoka S; Sanokawa R; Mori N (1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J. Biol. Chem. 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. PMID 9507002.
Cook KK; Fadool DA (2002). "Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase". J. Biol. Chem. 277 (15): 13268–80. doi:10.1074/jbc.M108898200. PMC 2779217. PMID 11812778.
Tarr PE, Roncarati R, Pelicci G, et al. (2002). "Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc". J. Biol. Chem. 277 (19): 16798–804. doi:10.1074/jbc.M110286200. PMID 11877420.
Liu HY; Meakin SO (2002). "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases". J. Biol. Chem. 277 (29): 26046–56. doi:10.1074/jbc.M111659200. PMID 12006576.
Miyake I, Hakomori Y, Shinohara A, et al. (2002). "Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines". Oncogene. 21 (38): 5823–34. doi:10.1038/sj.onc.1205735. PMID 12185581.
Pelicci G, Troglio F, Bodini A, et al. (2002). "The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway". Mol. Cell. Biol. 22 (20): 7351–63. doi:10.1128/MCB.22.20.7351-7363.2002. PMC 139827. PMID 12242309.
Nakamura T, Komiya M, Sone K, et al. (2003). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Mol. Cell. Biol. 22 (24): 8721–34. doi:10.1128/MCB.22.24.8721-8734.2002. PMC 139861. PMID 12446789.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Miyake I, Hakomori Y, Misu Y, et al. (2005). "Domain-specific function of ShcC docking protein in neuroblastoma cells". Oncogene. 24 (19): 3206–15. doi:10.1038/sj.onc.1208523. PMID 15735675.
Magrassi L, Conti L, Lanterna A, et al. (2005). "Shc3 affects human high-grade astrocytomas survival". Oncogene. 24 (33): 5198–206. doi:10.1038/sj.onc.1208708. PMID 15870690.
De Falco V, Guarino V, Malorni L, et al. (2005). "RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors". Oncogene. 24 (41): 6303–13. doi:10.1038/sj.onc.1208776. PMID 15940252.
Toschi E, Bacigalupo I, Strippoli R, et al. (2006). "HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway". Mol. Biol. Cell. 17 (4): 1985–94. doi:10.1091/mbc.E05-08-0717. PMC 1415297. PMID 16436505.
Li MD, Sun D, Lou XY, et al. (2007). "Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence". Mol. Psychiatry. 12 (5): 462–73. doi:10.1038/sj.mp.4001933. PMID 17179996.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[pmid8808684-1] Nakamura T; Sanokawa R; Sasaki Y; Ayusawa D; Oishi M; Mori N (November 1996). "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway". Oncogene. 13 (6): 1111–21. PMID 8808684.

[entrez-2] "Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3".

[pmid12446789-3] Nakamura, Takeshi; Komiya Misako; Sone Kiyoaki; Hirose Eiji; Gotoh Noriko; Morii Hiroshi; Ohta Yasutaka; Mori Nozomu (December 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Mol. Cell. Biol. United States. 22 (24): 8721–34. doi:10.1128/MCB.22.24.8721-8734.2002. ISSN 0270-7306. PMC 139861. PMID 12446789.

[pmid9507002-4] Nakamura, T; Muraoka S; Sanokawa R; Mori N (March 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J. Biol. Chem. UNITED STATES. 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. ISSN 0021-9258. PMID 9507002.

[pmid12074588-5] Suzuki, Shingo; Mizutani Masaharu; Suzuki Kenji; Yamada Masashi; Kojima Masami; Hatanaka Hiroshi; Koizumi Shinichi (June 2002). "Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor". Biochem. Biophys. Res. Commun. United States. 294 (5): 1087–92. doi:10.1016/S0006-291X(02)00606-X. ISSN 0006-291X. PMID 12074588.

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SHC3

Interactions

References

Further reading

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