SAT2

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Diamine acetyltransferase 2 is an enzyme that in humans is encoded by the SAT2 gene.[1][2][3] SAT2 maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate.[4]


References

  1. Coleman CS, Stanley BA, Jones AD, Pegg AE (Nov 2004). "Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism". Biochem J. 384 (Pt 1): 139–48. doi:10.1042/BJ20040790. PMC 1134097. PMID 15283699.
  2. Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL (Aug 2007). "Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha". J Biol Chem. 282 (32): 23572–80. doi:10.1074/jbc.M703504200. PMID 17558023.
  3. "Entrez Gene: SAT2 spermidine/spermine N1-acetyltransferase 2".
  4. Jenstad M, Quazi AZ, Zilberter M, Haglerød C, Berghuis P, Saddique N, Goiny M, Buntup D, Davanger S, S Haug FM, Barnes CA, McNaughton BL, Ottersen OP, Storm-Mathisen J, Harkany T, Chaudhry FA (May 2009). "System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate". Cereb Cortex. 19 (5): 1092–106. doi:10.1093/cercor/bhn151. PMID 18832333.

Further reading




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