S100 calcium binding protein A8

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S100 calcium binding protein A8
File:PBB Protein S100A8 image.jpg
PDB rendering based on 1mr8.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols S100A8 ; MIF; 60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag; MA387; MRP8; NIF; P8
External IDs Template:OMIM5 Template:MGI HomoloGene: 2225
RNA expression pattern
File:PBB GE S100A8 202917 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

S100 calcium binding protein A8, also known as S100A8, is a human gene.[1]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.[2]

References

  1. ↑ "Entrez Gene: S100A8 S100 calcium binding protein A8".
  2. ↑ "Entrez Gene: S100A8 S100 calcium binding protein A8".

Further reading

  • Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology". Trends Biochem. Sci. 21 (4): 134–40. PMID 8701470.
  • Kerkhoff C, Klempt M, Sorg C (1999). "Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9)". Biochim. Biophys. Acta. 1448 (2): 200–11. PMID 9920411.
  • Nacken W, Roth J, Sorg C, Kerkhoff C (2003). "S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity". Microsc. Res. Tech. 60 (6): 569–80. doi:10.1002/jemt.10299. PMID 12645005.
  • Roth J, Vogl T, Sorg C, Sunderkötter C (2004). "Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules". Trends Immunol. 24 (4): 155–8. PMID 12697438.
  • Rasmussen HH, van Damme J, Puype M; et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. PMID 1286667.
  • Lemarchand P, Vaglio M, Mauël J, Markert M (1992). "Translocation of a small cytosolic calcium-binding protein (MRP-8) to plasma membrane correlates with human neutrophil activation". J. Biol. Chem. 267 (27): 19379–82. PMID 1326551.
  • Schäfer T, Sachse GE, Gassen HG (1991). "The calcium-binding protein MRP-8 is produced by human pulmonary tumor cells". Biol. Chem. Hoppe-Seyler. 372 (1): 1–4. PMID 2039599.
  • Dorin JR, Emslie E, van Heyningen V (1991). "Related calcium-binding proteins map to the same subregion of chromosome 1q and to an extended region of synteny on mouse chromosome 3". Genomics. 8 (3): 420–6. PMID 2149559.
  • Wilkinson MM, Busuttil A, Hayward C; et al. (1989). "Expression pattern of two related cystic fibrosis-associated calcium-binding proteins in normal and abnormal tissues". J. Cell. Sci. 91 ( Pt 2): 221–30. PMID 3267695.
  • Odink K, Cerletti N, Brüggen J; et al. (1987). "Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis". Nature. 330 (6143): 80–2. doi:10.1038/330080a0. PMID 3313057.
  • Lagasse E, Clerc RG (1988). "Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation". Mol. Cell. Biol. 8 (6): 2402–10. PMID 3405210.
  • Dorin JR, Novak M, Hill RE; et al. (1987). "A clue to the basic defect in cystic fibrosis from cloning the CF antigen gene". Nature. 326 (6113): 614–7. doi:10.1038/326614a0. PMID 3561500.
  • Schäfer BW, Wicki R, Engelkamp D; et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. PMID 7759097.
  • Umekawa T, Kurita T (1995). "Calprotectin-like protein is related to soluble organic matrix in calcium oxalate urinary stone". Biochem. Mol. Biol. Int. 34 (2): 309–13. PMID 7849642.
  • Engelkamp D, Schäfer BW, Mattei MG; et al. (1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6547–51. PMID 8341667.
  • Roth J, Burwinkel F, van den Bos C; et al. (1993). "MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner". Blood. 82 (6): 1875–83. PMID 8400238.
  • Miyasaki KT, Bodeau AL, Murthy AR, Lehrer RI (1993). "In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena". J. Dent. Res. 72 (2): 517–23. PMID 8423249.
  • Marti T, Erttmann KD, Gallin MY (1996). "Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin". Biochem. Biophys. Res. Commun. 221 (2): 454–8. doi:10.1006/bbrc.1996.0616. PMID 8619876.

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