S-formylglutathione hydrolase

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In enzymology, a S-formylglutathione hydrolase (EC is an enzyme that catalyzes the chemical reaction

S-formylglutathione + H2O glutathione + formate

Thus, the two substrates of this enzyme are S-formylglutathione and H2O, whereas its two products are glutathione and formate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is S-formylglutathione hydrolase. This enzyme participates in methane metabolism.


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  • Uotila L (1973). "Preparation and assay of glutathione thiol esters. Survey of human liver glutathione thiol esterases". Biochemistry. 12: 3938&ndash, 43. PMID 4200890.
  • Uotila L, Koivusalo M (1974). "Purification and properties of S-formylglutathione hydrolase from human liver". J. Biol. Chem. 249: 7664&ndash, 72. PMID 4436331.
  • Harms N, Ras J, Reijnders WN, van Spanning RJ, Stouthamer AH (1996). "S-formylglutathione hydrolase of Paracoccus denitrificans is homologous to human esterase D: a universal pathway for formaldehyde detoxification?". J. Bacteriol. 178: 6296&ndash, 9. PMID 8892832.

External links

The CAS registry number for this enzyme class is 50812-21-0.

Gene Ontology (GO) codes