Rotor syndrome

You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.

Rotor syndrome Classification and external resources
Bilirubin
ICD-10	E80.6
ICD-9	277.4
OMIM	237450
DiseasesDB	11671
MeSH	D006933

WikiDoc Resources for Rotor syndrome
Articles
Most recent articles on Rotor syndrome Most cited articles on Rotor syndrome Review articles on Rotor syndrome Articles on Rotor syndrome in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Rotor syndrome Images of Rotor syndrome Photos of Rotor syndrome Podcasts & MP3s on Rotor syndrome Videos on Rotor syndrome
Evidence Based Medicine
Cochrane Collaboration on Rotor syndrome Bandolier on Rotor syndrome TRIP on Rotor syndrome
Clinical Trials
Ongoing Trials on Rotor syndrome at Clinical Trials.gov Trial results on Rotor syndrome Clinical Trials on Rotor syndrome at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Rotor syndrome NICE Guidance on Rotor syndrome NHS PRODIGY Guidance FDA on Rotor syndrome CDC on Rotor syndrome
Books
Books on Rotor syndrome
News
Rotor syndrome in the news Be alerted to news on Rotor syndrome News trends on Rotor syndrome
Commentary
Blogs on Rotor syndrome
Definitions
Definitions of Rotor syndrome
Patient Resources / Community
Patient resources on Rotor syndrome Discussion groups on Rotor syndrome Patient Handouts on Rotor syndrome Directions to Hospitals Treating Rotor syndrome Risk calculators and risk factors for Rotor syndrome
Healthcare Provider Resources
Symptoms of Rotor syndrome Causes & Risk Factors for Rotor syndrome Diagnostic studies for Rotor syndrome Treatment of Rotor syndrome
Continuing Medical Education (CME)
CME Programs on Rotor syndrome
International
Rotor syndrome en Espanol Rotor syndrome en Francais
Business
Rotor syndrome in the Marketplace Patents on Rotor syndrome
Experimental / Informatics
List of terms related to Rotor syndrome

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Rotor syndrome is a rare, benign autosomal recessive disorder of unknown origin.

Presentation

It has many things in common with Dubin-Johnson syndrome except that in Rotor Syndrome, the liver cells are not pigmented. The main symptom is a non-itching jaundice. There is a rise in bilirubin in the patient's serum, mainly of the conjugated type.

	Rotor syndrome	DJS
appearance of liver	normal histology and appearance	liver has black pigmentation
gallbladder visualization	gallbladder can be visualized by oral cholecystogram	gallbladder cannot be visualized
total urine coproporphyrin content	high with <70% being isomer 1	normal with >80% being isomer 1 (normal urine contains more of isomer 3 than isomer 1)

Treatment

The liver is otherwise normal, and there is no need to treat this condition. It can be differentiated from Dubin Johnson syndrome by measuring the difference in urinary poryphrins. In Rotor syndrome there is an associated marked increase in urinary excretion of coproporyhrin I and III with < 80% being the I isomer.

Eponym

Rotor syndrome is named after the Filipino internist, Arturo Belleza Rotor (1907-1988).^[1]

See also

• Jaundice
• Bilirubin metabolism
• Dubin-Johnson syndrome
• Gilbert syndrome
• Crigler-Najjar syndrome

References

1. ↑ synd/2296 at Who Named It

External links

• med/1065 at eMedicine - article on eMedicine on conjugated hyperbilirubinemia

v • d • e Metabolic pathology / Inborn error of metabolism (E70-90, 270-279)
Amino acid	Aromatic (Phenylketonuria, Alkaptonuria, Ochronosis, Tyrosinemia, Albinism, Histidinemia) - Branched chain (Maple syrup urine disease, Propionic acidemia, Methylmalonic acidemia, Isovaleric acidemia, 3-Methylcrotonyl-CoA carboxylase deficiency) - Transport (Cystinuria, Cystinosis, Hartnup disease, Fanconi syndrome, Oculocerebrorenal syndrome) - Sulfur (Homocystinuria, Cystathioninuria) - Urea cycle disorder (N-Acetylglutamate synthase deficiency, Carbamoyl phosphate synthetase I deficiency, Ornithine transcarbamylase deficiency, Citrullinemia, Argininosuccinic aciduria, Hyperammonemia) - Glutaric acidemia type 1 - Sarcosinemia
Carbohydrate	Lactose intolerance - Glycogen storage disease (type I, type II, type III, type IV, type V, type VI, type VII) - fructose metabolism (Fructose intolerance, Fructose bisphosphatase deficiency, Essential fructosuria) - galactose metabolism (Galactosemia, Galactose-1-phosphate uridylyltransferase galactosemia, Galactokinase deficiency) - other intestinal carbohydrate absorption (Glucose-galactose malabsorption, Sucrose intolerance) - pyruvate metabolism and gluconeogenesis (PCD, PDHA) - Pentosuria - Renal glycosuria
Lipid storage	Sphingolipidoses/Gangliosidoses: GM2 gangliosidoses (Sandhoff disease, Tay-Sachs disease) - GM1 gangliosidoses - Mucolipidosis type IV - Gaucher's disease - Niemann-Pick disease - Farber disease - Fabry's disease - Metachromatic leukodystrophy - Krabbe disease Neuronal ceroid lipofuscinosis (Batten disease) - Cerebrotendineous xanthomatosis - Cholesteryl ester storage disease (Wolman disease)
Other lipid	Lipoprotein/lipidemias: Hyperlipidemia - Hypercholesterolemia - Familial hypercholesterolemia - Xanthoma - Combined hyperlipidemia - Lecithin cholesterol acyltransferase deficiency - Tangier disease - Abetalipoproteinemia Fatty acid: Adrenoleukodystrophy - Carnitine (Primary, I, II)
Mineral	Cu Wilson's disease/Menkes disease - Fe Haemochromatosis - Zn Acrodermatitis enteropathica - PO43− Hypophosphatemia/Hypophosphatasia - Mg2+ Hypermagnesemia/Hypomagnesemia - Ca2+ Hypercalcaemia/Hypocalcaemia/Disorders of calcium metabolism
Fluid, electrolyte and acid-base balance	Electrolyte disturbance - Na+ Hypernatremia/Hyponatremia - Acidosis (Metabolic, Respiratory, Lactic) - Alkalosis (Metabolic, Respiratory) - Mixed disorder of acid-base balance - H2O Dehydration/Hypervolemia - K+ Hypokalemia/Hyperkalemia - Cl− Hyperchloremia/Hypochloremia
Purine and pyrimidine	Hyperuricemia - Lesch-Nyhan syndrome - Xanthinuria
Porphyrin	Acute intermittent, Gunther's, Cutanea tarda, Erythropoietic, Hepatoerythropoietic, Hereditary copro-, Variegate
Bilirubin	Unconjugated (Gilbert's syndrome, Crigler-Najjar syndrome) - Conjugated (Dubin-Johnson syndrome, Rotor syndrome)
Glycosaminoglycan	Mucopolysaccharidosis - 1:Hurler/Hunter - 3:Sanfilippo - 4:Morquio - 6:Maroteaux-Lamy - 7:Sly
Glycoprotein	Mucolipidosis - I-cell disease - Pseudo-Hurler polydystrophy - Aspartylglucosaminuria - Fucosidosis - Alpha-mannosidosis - Sialidosis
Other	Alpha 1-antitrypsin deficiency - Cystic fibrosis - Amyloidosis (Familial Mediterranean fever) - Acatalasia

v • d • e Heme metabolism disorders (E80, 277.1, 277.4)
Porphyrin	Hepatic porphyria: Acute intermittent - Cutanea tarda/Hepatoerythropoietic - Hereditary copro- - Variegate Erythropoietic: Gunther's
Hereditary hyperbilirubinemia	Unconjugated: Lucey-Driscoll syndrome - Gilbert's syndrome - Crigler-Najjar syndrome Conjugated: Dubin-Johnson syndrome - Rotor syndrome
see also porphyrin metabolism enzymes, intermediates

v • d • e WikiDoc Research Resources for Rotor syndrome
Articles on Rotor syndrome	Most recent articles on Rotor syndrome • Most cited articles on Rotor syndrome • Review articles on Rotor syndrome • Articles on Rotor syndrome in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Rotor syndrome	Powerpoint slides on Rotor syndrome • Images of Rotor syndrome • Photos of Rotor syndrome • Podcasts & MP3s on Rotor syndrome • Videos on Rotor syndrome
Evidence Based Medicine Regarding Rotor syndrome	Cochrane Collaboration on Rotor syndrome • Bandolier on Rotor syndrome • TRIP on Rotor syndrome
Cost Effectiveness of Rotor syndrome	Cost Effectiveness of Rotor syndrome
Clinical Trials Involving Rotor syndrome	Ongoing Trials on Rotor syndrome at Clinical Trials.gov • Trial results on Rotor syndrome • Clinical Trials on Rotor syndrome at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Rotor syndrome	US National Guidelines Clearinghouse on Rotor syndrome • NICE Guidance on Rotor syndrome • NHS PRODIGY Guidance • FDA on Rotor syndrome • CDC on Rotor syndrome
Textbook Information on Rotor syndrome	Books and Textbook Information on Rotor syndrome
Pharmacology Resources on Rotor syndrome	Dosing of Rotor syndrome • Drug interactions with Rotor syndrome • Side effects of Rotor syndrome • Allergic reactions to Rotor syndrome • Overdose information on Rotor syndrome • Carcinogenicity information on Rotor syndrome • Rotor syndrome in pregnancy • Pharmacokinetics of Rotor syndrome •
Genetics, Pharmacogenomics, and Proteinomics of Rotor syndrome	Genetics of Rotor syndrome • Pharmacogenomics of Rotor syndrome • Proteomics of Rotor syndrome
Newstories on Rotor syndrome	Rotor syndrome in the news • Be alerted to news on Rotor syndrome • News trends on Rotor syndrome
Commentary on Rotor syndrome	Blogs on Rotor syndrome
Patient Resources on Rotor syndrome	Patient resources on Rotor syndrome • Discussion groups on Rotor syndrome • Patient Handouts on Rotor syndrome • Directions to Hospitals Treating Rotor syndrome • Risk calculators and risk factors for Rotor syndrome
Healthcare Provider Resources on Rotor syndrome	Symptoms of Rotor syndrome • Causes & Risk Factors for Rotor syndrome • Diagnostic studies for Rotor syndrome • Treatment of Rotor syndrome
Continuing Medical Education (CME) Programs on Rotor syndrome	CME Programs on Rotor syndrome
International Resources on Rotor syndrome	Rotor syndrome en Espanol • Rotor syndrome en Francais
Business Resources on Rotor syndrome	Rotor syndrome in the Marketplace • Patents on Rotor syndrome
Informatics Resources on Rotor syndrome	List of terms related to Rotor syndrome

de:Rotor-Syndrom