Roseola historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]
Overview
For the first time, Zahorsky of St. Louis in 1910 described a febrile exanthem occurring in infants which he termed roseola. Human herpes virus 6 was first identified in 1986.
Historical Perspective
- For the first time, Zahorsky of St. Louis in 1910 described a febrile exanthem occurring in infants which he termed roseola.
- In 1986, Human herpes virus 6 (HHV6), the main causative agent of roseola disease was first isolated from patients who were diagnosed with HIV AIDS or a lymphoproliferative disorder from the peripheral blood leukocytes. [1]
- The two different variants of HHV 6 discovered by Frenkel, Ablashi and Aubin are variant A and Variant B HHV 6 strains.[2][3][4]
- HHV 6A has been found to be more associated with the development of roseola.
References
- ↑ Salahuddin SZ, Ablashi DV, Markham PD, Josephs SF, Sturzenegger S, Kaplan M; et al. (1986). "Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders". Science. 234 (4776): 596–601. PMID 2876520.
- ↑ Schirmer EC, Wyatt LS, Yamanishi K, Rodriguez WJ, Frenkel N (1991). "Differentiation between two distinct classes of viruses now classified as human herpesvirus 6". Proc Natl Acad Sci U S A. 88 (13): 5922–6. PMC 51990. PMID 1648234.
- ↑ Ablashi DV, Balachandran N, Josephs SF, Hung CL, Krueger GR, Kramarsky B; et al. (1991). "Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates". Virology. 184 (2): 545–52. PMID 1653487.
- ↑ Aubin JT, Collandre H, Candotti D, Ingrand D, Rouzioux C, Burgard M; et al. (1991). "Several groups among human herpesvirus 6 strains can be distinguished by Southern blotting and polymerase chain reaction". J Clin Microbiol. 29 (2): 367–72. PMC 269769. PMID 1848868.